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Churcher, Ian
65  Ergebnisse:
Personensuche X
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1

The rise and rise of protein degradation: Opportunities and..:

Hughes, Scott J. ; Testa, Andrea ; Thompson, Nicola.
Drug Discovery Today.  26 (2021)  12 - p. 2889-2897 , 2021
Link: https://doi.org/10.1016/..
 
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2

Optimization of a Series of RIPK2 PROTACs:

Miah, Afjal H. ; Smith, Ian E. D. ; Rackham, Mark...
Journal of Medicinal Chemistry.  64 (2021)  17 - p. 12978-13003 , 2021
Link: https://doi.org/10.1021/..
 
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3

Extended pharmacodynamic responses observed upon PROTAC-med..:

Mares, Alina ; Miah, Afjal H. ; Smith, Ian E. D....
Communications Biology.  3 (2020)  1 - p. , 2020
Link: https://doi.org/10.1038/..
 
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4

Structural Insights into PROTAC-Mediated Degradation of Bcl..:

Chung, Chun-wa ; Dai, Han ; Fernandez, Esther...
ACS Chemical Biology.  15 (2020)  9 - p. 2316-2323 , 2020
Link: https://doi.org/10.1021/..
 
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5

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC ..:

Bassi, Zuni I. ; Fillmore, Martin C. ; Miah, Afjal H....
ACS Chemical Biology.  13 (2018)  10 - p. 2862-2867 , 2018
Link: https://doi.org/10.1021/..
 
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6

Protac-Induced Protein Degradation in Drug Discovery: Break..:

Churcher, Ian
Journal of Medicinal Chemistry.  61 (2017)  2 - p. 444-452 , 2017
Link: https://doi.org/10.1021/..
 
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7

Synthesis and Demonstration of the Biological Relevance of ..:

Foley, Daniel J. ; Craven, Philip G. E. ; Collins, Patrick M....
Chemistry – A European Journal.  23 (2017)  60 - p. 15227-15232 , 2017
Link: https://doi.org/10.1002/..
 
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8

Small molecule-mediated protein knockdown as a new approach..:

Tinworth, Christopher P. ; Lithgow, Hannah ; Churcher, Ian
MedChemComm.  7 (2016)  12 - p. 2206-2216 , 2016
Link: https://doi.org/10.1039/..
 
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9

Structurally Diverse Mitochondrial Branched Chain Aminotran..:

Borthwick, Jennifer A. ; Ancellin, Nicolas ; Bertrand, Sophie M....
Journal of Medicinal Chemistry.  59 (2016)  6 - p. 2452-2467 , 2016
Link: https://doi.org/10.1021/..
 
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10

Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Sy..:

Moragas, Toni ; Liffey, Ryan M. ; Regentová, Dominika...
Angewandte Chemie International Edition.  55 (2016)  34 - p. 10047-10051 , 2016
Link: https://doi.org/10.1002/..
 
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11

Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Sy..:

Moragas, Toni ; Liffey, Ryan M. ; Regentová, Dominika...
Angewandte Chemie.  128 (2016)  34 - p. 10201-10205 , 2016
Link: https://doi.org/10.1002/..
 
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12

A divergent synthetic approach to diverse molecular scaffol..:

Colomer, Ignacio ; Empson, Christopher J. ; Craven, Philip...
Chemical Communications.  52 (2016)  45 - p. 7209-7212 , 2016
Link: https://doi.org/10.1039/..
 
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13

Small molecule‐induced catalytic ubiquitination of non‐natu..:

Bondeson, Daniel ; Pancevac, Christina ; Kruidenier, Laurens...
The FASEB Journal.  29 (2015)  S1 - p. , 2015
Link: https://doi.org/10.1096/..
 
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14

A systematic approach to diverse, lead-like scaffolds from ..:

Foley, Daniel J. ; Doveston, Richard G. ; Churcher, Ian..
Chemical Communications.  51 (2015)  56 - p. 11174-11177 , 2015
Link: https://doi.org/10.1039/..
 
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15

A unified lead-oriented synthesis of over fifty molecular s..:

Doveston, Richard G. ; Tosatti, Paolo ; Dow, Mark...
Organic & Biomolecular Chemistry.  13 (2015)  3 - p. 859-865 , 2015
Link: https://doi.org/10.1039/..
 
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