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X
Dawson, Lee A.
1765  Ergebnisse:
Personensuche X
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1

Differential contribution of THIK-1 K+ channels and P2X7 re..:

Rifat, Ali ; Ossola, Bernardino ; Bürli, Roland W....
Journal of Neuroinflammation.  21 (2024)  1 - p. , 2024
Link: https://doi.org/10.1186/..
 
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2

Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhi..:

Bürli, Roland W. ; Doyle, Kevin J. ; Dickson, Louise...
ACS Medicinal Chemistry Letters.  15 (2024)  5 - p. 646-652 , 2024
Link: https://doi.org/10.1021/..
 
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3

Fragment-Based Discovery of a Series of Allosteric-Binding ..:

Palmer, Nick ; Agnew, Christopher ; Benn, Caroline...
Journal of Medicinal Chemistry.  67 (2024)  13 - p. 11168-11181 , 2024
Link: https://doi.org/10.1021/..
 
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4

Discovery and first-time disclosure of CVN766, an exquisite..:

Glen, Angela ; Bürli, Roland W. ; Livermore, David...
Bioorganic & Medicinal Chemistry Letters.  100 (2024)  - p. 129629 , 2024
Link: https://doi.org/10.1016/..
 
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5

Discovery and Characterization of Novel CNS-Penetrant GPR55..:

Hewer, Richard C. ; Christie, Louisa A. ; Doyle, Kevin J....
Journal of Medicinal Chemistry.  66 (2023)  18 - p. 12858-12876 , 2023
Link: https://doi.org/10.1021/..
 
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6

A Covalent Binding Mode of a Pyrazole‐Based CD38 Inhibitor:

Doyle, Kevin ; Roberts, Maxine ; Harvey, Jenna...
Helvetica Chimica Acta.  106 (2023)  9 - p. , 2023
Link: https://doi.org/10.1002/..
 
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7

Discovery of CVN417, a Novel Brain-Penetrant α6-Containing ..:

Christie, Louisa A. ; Brice, Nicola L. ; Rowland, Anna...
Journal of Medicinal Chemistry.  66 (2023)  17 - p. 11718-11731 , 2023
Link: https://doi.org/10.1021/..
 
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8

Discovery of CVN636: A Highly Potent, Selective, and CNS Pe..:

Dickson, Louise ; Teall, Martin ; Chevalier, Elodie...
ACS Medicinal Chemistry Letters.  14 (2023)  4 - p. 442-449 , 2023
Link: https://doi.org/10.1021/..
 
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9

NETS‐seq advances the understanding of neuronal vulnerabili..:

Bayraktar, Gonca ; Christie, Louisa ; Brice, Nicola...
Alzheimer's & Dementia.  19 (2023)  S13 - p. , 2023
Link: https://doi.org/10.1002/..
 
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10

Synthesis and SAR of novel GPR39 agonists and positive allo..:

Burley, Russell ; Hewer, Richard C. ; Teall, Martin...
Bioorganic & Medicinal Chemistry Letters.  61 (2022)  - p. 128607 , 2022
Link: https://doi.org/10.1016/..
 
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11

Fragment-Based Discovery of a Novel, Brain Penetrant, Orall..:

Tamanini, Emiliano ; Miyamura, Shin ; Buck, Ildiko M....
ACS Medicinal Chemistry Letters.  13 (2022)  10 - p. 1591-1597 , 2022
Link: https://doi.org/10.1021/..
 
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12

The two pore potassium channel THIK‐1 regulates NLRP3 infla..:

Drinkall, Samuel ; Lawrence, Catherine B. ; Ossola, Bernadino...
Glia.  70 (2022)  7 - p. 1301-1316 , 2022
Link: https://doi.org/10.1002/..
 
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13

Identification of CVN058, a Novel Brain Penetrant, Selectiv..:

Brice, Nicola ; Dawson, Lee A. ; Margolin, David H....
Biological Psychiatry.  89 (2021)  9 - p. S26 , 2021
Link: https://doi.org/10.1016/..
 
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14

CVN058, a 5-HT3 Receptor Antagonist, Shows Acute, Dose Depe..:

Sehatpour, Pejman ; De Baun, Heloise ; Javitt, Daniel...
Biological Psychiatry.  89 (2021)  9 - p. S27 , 2021
Link: https://doi.org/10.1016/..
 
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15

The role of SQSTM1 (p62) in mitochondrial function and clea..:

Poon, Anna ; Saini, Harpreet ; Sethi, Siddharth...
Stem Cell Reports.  16 (2021)  5 - p. 1276-1289 , 2021
Link: https://doi.org/10.1016/..
 
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