E-LIB Suche - Ergebnisse für: Goodacre, Simon

1

Discovery of GNE-502 as an orally bioavailable and potent d..:

Zbieg, Jason R. ; Liang, Jun ; Li, Jun...
Bioorganic & Medicinal Chemistry Letters. 50 (2021) - p. 128335 , 2021

Link: https://doi.org/10.1016/..

2

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable S..:

Liang, Jun ; Zbieg, Jason R. ; Blake, Robert A....
Journal of Medicinal Chemistry. 64 (2021) 16 - p. 11841-11856 , 2021

Link: https://doi.org/10.1021/..

3

Discovery of GNE-149 as a Full Antagonist and Efficient Deg..:

Liang, Jun ; Blake, Robert ; Chang, Jae...
ACS Medicinal Chemistry Letters. 11 (2020) 6 - p. 1342-1347 , 2020

Link: https://doi.org/10.1021/..

4

Discovery of a C-8 hydroxychromene as a potent degrader of ..:

Labadie, Sharada S. ; Li, Jun ; Blake, Robert A....
Bioorganic & Medicinal Chemistry Letters. 29 (2019) 16 - p. 2090-2093 , 2019

Link: https://doi.org/10.1016/..

5

Identification of an imidazopyridine scaffold to generate p..:

Liang, Jun ; Van Abbema, Anne ; Balazs, Mercedesz...
Bioorganic & Medicinal Chemistry Letters. 27 (2017) 18 - p. 4370-4376 , 2017

Link: https://doi.org/10.1016/..

6

Mitigation of Acetylcholine Esterase Activity in the 1,7-Di..:

Gazzard, Lewis ; Williams, Karen ; Chen, Huifen...
Journal of Medicinal Chemistry. 58 (2015) 12 - p. 5053-5074 , 2015

Link: https://doi.org/10.1021/..

7

Discovery of the 1,7-diazacarbazole class of inhibitors of ..:

Gazzard, Lewis ; Appleton, Brent ; Chapman, Kerry...
Bioorganic & Medicinal Chemistry Letters. 24 (2014) 24 - p. 5704-5709 , 2014

Link: https://doi.org/10.1016/..

8

Discovery of Imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 S..:

Russell, Michael G. N. ; Carling, Robert W. ; Street, Leslie J....
Journal of Medicinal Chemistry. 49 (2006) 4 - p. 1235-1238 , 2006

Link: https://doi.org/10.1021/..

9

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical ..:

Humphries, Alexander C. ; Gancia, Emanuela ; Gilligan, Myra T....
Bioorganic & Medicinal Chemistry Letters. 16 (2006) 6 - p. 1518-1522 , 2006

Link: https://doi.org/10.1016/..

10

Evidence for a Significant Role of α3-Containing GABAARecep..:

Dias, Rebecca ; Sheppard, Wayne F. A. ; Fradley, Rosa L....
The Journal of Neuroscience. 25 (2005) 46 - p. 10682-10688 , 2005

Link: https://doi.org/10.1523/..

11

3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity..:

Rowley, Michael ; Hallett, David J. ; Goodacre, Simon...
Journal of Medicinal Chemistry. 44 (2001) 10 - p. 1603-1614 , 2001

Link: https://doi.org/10.1021/..

12

3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-p..:

Crawforth, James ; Goodacre, Simon ; Maxey, Robert...
Bioorganic & Medicinal Chemistry Letters. 10 (2000) 24 - p. 2701-2703 , 2000

Link: https://doi.org/10.1016/..

13

3-(Piperazinylpropyl)indoles: Selective, Orally Bioavailab..:

Chambers, Mark S. ; Street, Leslie J. ; Goodacre, Simon...
Journal of Medicinal Chemistry. 42 (1999) 4 - p. 691-705 , 1999

Link: https://doi.org/10.1021/..

14

Discovery of a class of highly potent Janus Kinase 1/2 (JAK..:

Zak, Mark ; Hanan, Emily J. ; Lupardus, Patrick...
Bioorganic & Medicinal Chemistry Letters. 29 (2019) 12 - p. 1522-1531 , 2019

Link: https://doi.org/10.1016/..

15

Identification of an Orally Bioavailable, Potent, and Selec..:

Blackaby, Wesley P. ; Lewis, Richard T. ; Thomson, Joanne L....
ACS Medicinal Chemistry Letters. 1 (2010) 7 - p. 350-354 , 2010

Link: https://doi.org/10.1021/..