E-LIB Suche - Ergebnisse für: Heightman, Tom D.

1

Fragment-Based Discovery of a Novel, Brain Penetrant, Orall..:

Tamanini, Emiliano ; Miyamura, Shin ; Buck, Ildiko M....
ACS Medicinal Chemistry Letters. 13 (2022) 10 - p. 1591-1597 , 2022

Link: https://doi.org/10.1021/..

2

Fragment-based drug discovery: opportunities for organic sy..:

St. Denis, Jeffrey D. ; Hall, Richard J. ; Murray, Christopher W...
RSC Medicinal Chemistry. 12 (2021) 3 - p. 321-329 , 2021

Link: https://doi.org/10.1039/..

3

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhib..:

Norton, David ; Bonnette, William G. ; Callahan, James F....
Journal of Medicinal Chemistry. 64 (2021) 21 - p. 15949-15972 , 2021

Link: https://doi.org/10.1021/..

4

Discovery of ASTX029, A Clinical Candidate Which Modulates ..:

Heightman, Tom D. ; Berdini, Valerio ; Bevan, Luke...
Journal of Medicinal Chemistry. 64 (2021) 16 - p. 12286-12303 , 2021

Link: https://doi.org/10.1021/..

5

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyri..:

Johannes, Jeffrey W. ; Balazs, Amber ; Barratt, Derek...
Journal of Medicinal Chemistry. 64 (2021) 19 - p. 14498-14512 , 2021

Link: https://doi.org/10.1021/..

6

Enabling synthesis in fragment-based drug discovery by reac..:

Grainger, Rachel ; Heightman, Tom D. ; Ley, Steven V...
Chemical Science. 10 (2019) 8 - p. 2264-2271 , 2019

Link: https://doi.org/10.1039/..

7

Structure–Activity and Structure–Conformation Relationships..:

Heightman, Tom D. ; Callahan, James F. ; Chiarparin, Elisabetta...
Journal of Medicinal Chemistry. 62 (2019) 9 - p. 4683-4702 , 2019

Link: https://doi.org/10.1021/..

8

Fragment-Based Discovery of a Potent, Orally Bioavailable I..:

Heightman, Tom D. ; Berdini, Valerio ; Braithwaite, Hannah...
Journal of Medicinal Chemistry. 61 (2018) 11 - p. 4978-4992 , 2018

Link: https://doi.org/10.1021/..

9

Quantitation of ERK1/2 inhibitor cellular target occupancie..:

Lebraud, Honorine ; Surova, Olga ; Courtin, Aurélie...
Chemical Science. 9 (2018) 45 - p. 8608-8618 , 2018

Link: https://doi.org/10.1039/..

10

Highly Potent Clickable Probe for Cellular Imaging of MDM2 ..:

Lebraud, Honorine ; Noble, Richard A. ; Phillips, Nicole...
Bioconjugate Chemistry. 29 (2018) 6 - p. 2100-2106 , 2018

Link: https://doi.org/10.1021/..

11

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Ant..:

Tamanini, Emiliano ; Buck, Ildiko M. ; Chessari, Gianni...
Journal of Medicinal Chemistry. 60 (2017) 11 - p. 4611-4625 , 2017

Link: https://doi.org/10.1021/..

12

Visualization of Endogenous ERK1/2 in Cells with a Bioortho..:

Sipthorp, James ; Lebraud, Honorine ; Gilley, Rebecca...
Bioconjugate Chemistry. 28 (2017) 6 - p. 1677-1683 , 2017

Link: https://doi.org/10.1021/..

13

Structure of the Epigenetic Oncogene MMSET and Inhibition b..:

Tisi, Dominic ; Chiarparin, Elisabetta ; Tamanini, Emiliano...
ACS Chemical Biology. 11 (2016) 11 - p. 3093-3105 , 2016

Link: https://doi.org/10.1021/..

14

In-gel activity-based protein profiling of a clickable cova..:

Lebraud, Honorine ; Wright, David J. ; East, Charlotte E....
Molecular BioSystems. 12 (2016) 9 - p. 2867-2874 , 2016

Link: https://doi.org/10.1039/..

15

Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acety..:

Sekirnik (née Measures), Angelina R. ; Hewings, David S. ; Theodoulou, Natalie H....
Angewandte Chemie. 128 (2016) 29 - p. 8493-8497 , 2016

Link: https://doi.org/10.1002/..