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X
Newell, David R.
3094  Ergebnisse:
Personensuche X
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1

Parallel Optimization of Potency and Pharmacokinetics Leadi..:

Miller, Duncan C. ; Reuillon, Tristan ; Molyneux, Lauren...
Journal of Medicinal Chemistry.  65 (2022)  9 - p. 6513-6540 , 2022
Link: https://doi.org/10.1021/..
 
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2

Structure-Based Design of Potent and Orally Active Isoindol..:

Chessari, Gianni ; Hardcastle, Ian R. ; Ahn, Jong Sook...
Journal of Medicinal Chemistry.  64 (2021)  7 - p. 4071-4088 , 2021
Link: https://doi.org/10.1021/..
 
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3

2-Arylamino-6-ethynylpurines are cysteine-targeting irrever..:

Matheson, Christopher J. ; Coxon, Christopher R. ; Bayliss, Richard...
RSC Medicinal Chemistry.  11 (2020)  6 - p. 707-731 , 2020
Link: https://doi.org/10.1039/..
 
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4

Identification of a novel orally bioavailable ERK5 inhibito..:

Myers, Stephanie M. ; Miller, Duncan C. ; Molyneux, Lauren...
European Journal of Medicinal Chemistry.  178 (2019)  - p. 530-543 , 2019
Link: https://doi.org/10.1016/..
 
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5

A successful collaboration between academia, biotech and ph..:

Murray, Christopher W. ; Newell, David R. ; Angibaud, Patrick
MedChemComm.  10 (2019)  9 - p. 1509-1511 , 2019
Link: https://doi.org/10.1039/..
 
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6

Selective DNA-PKcs inhibition extends the therapeutic index..:

Willoughby, Catherine E. ; Jiang, Yanyan ; Thomas, Huw D....
Journal of Clinical Investigation.  130 (2019)  1 - p. 258-271 , 2019
Link: https://doi.org/10.1172/..
 
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7

Preclinical evaluation of the first intravenous small molec..:

Chen, Lindi ; Pastorino, Fabio ; Berry, Philip...
International Journal of Cancer.  144 (2019)  12 - p. 3146-3159 , 2019
Link: https://doi.org/10.1002/..
 
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8

Highly Potent Clickable Probe for Cellular Imaging of MDM2 ..:

Lebraud, Honorine ; Noble, Richard A. ; Phillips, Nicole...
Bioconjugate Chemistry.  29 (2018)  6 - p. 2100-2106 , 2018
Link: https://doi.org/10.1021/..
 
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9

PARP inhibitor rucaparib induces changes in NAD levels in c..:

Almeida, Gilberto S. ; Bawn, Carlo M. ; Galler, Martin...
NMR in Biomedicine.  30 (2017)  9 - p. , 2017
Link: https://doi.org/10.1002/..
 
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10

Sensitizing Ewing sarcoma to chemo- and radiotherapy by inh..:

Vormoor, Britta ; Schlosser, Yvonne T. ; Blair, Helen...
Oncotarget.  8 (2017)  69 - p. 113418-113430 , 2017
Link: https://doi.org/10.18632..
 
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11

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activit..:

Coxon, Christopher R. ; Anscombe, Elizabeth ; Harnor, Suzannah J....
Journal of Medicinal Chemistry.  60 (2017)  5 - p. 1746-1767 , 2017
Link: https://doi.org/10.1021/..
 
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12

TP53 mutant MDM2-amplified cell lines selected for resistan..:

Drummond, Catherine J. ; Esfandiari, Arman ; Liu, Junfeng...
Oncotarget.  7 (2016)  29 - p. 46203-46218 , 2016
Link: https://doi.org/10.18632..
 
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13

Enhanced anti-tumour activity of the combination of the nov..:

Haagensen, Emma J. ; Thomas, Huw D. ; Schmalix, Wolfgang A....
Cancer Chemotherapy and Pharmacology.  78 (2016)  6 - p. 1269-1281 , 2016
Link: https://doi.org/10.1007/..
 
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14

Pre-clinical use of isogenic cell lines and tumours in vitr..:

Haagensen, Emma J. ; Thomas, Huw D. ; Mudd, Clare...
European Journal of Cancer.  56 (2016)  - p. 69-76 , 2016
Link: https://doi.org/10.1016/..
 
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15

Combined PI3K and CDK2 inhibition induces cell death and en..:

Beale, Gary ; Haagensen, Emma J ; Thomas, Huw D...
British Journal of Cancer.  115 (2016)  6 - p. 682-690 , 2016
Link: https://doi.org/10.1038/..
 
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