E-LIB Suche - Ergebnisse für: Rueeger, Heinrich

1

Identification of NVP-CLR457 as an Orally Bioavailable Non-..:

Fairhurst, Robin A. ; Furet, Pascal ; Imbach-Weese, Patricia...
Journal of Medicinal Chemistry. 65 (2022) 12 - p. 8345-8379 , 2022

Link: https://doi.org/10.1021/..

2

Synthesis of the Potent, Selective, and Efficacious β-Secre..:

Rueeger, Heinrich ; Lueoend, Rainer ; Machauer, Rainer...
Journal of Medicinal Chemistry. 64 (2021) 8 - p. 4677-4696 , 2021

Link: https://doi.org/10.1021/..

3

BET bromodomain inhibitors regulate keratinocyte plasticity:

Schutzius, Gabi ; Kolter, Christian ; Bergling, Sebastian...
Nature Chemical Biology. 17 (2021) 3 - p. 280-290 , 2021

Link: https://doi.org/10.1038/..

4

Discovery of Umibecestat (CNP520): A Potent, Selective, and..:

Machauer, Rainer ; Lueoend, Rainer ; Hurth, Konstanze...
Journal of Medicinal Chemistry. 64 (2021) 20 - p. 15262-15279 , 2021

Link: https://doi.org/10.1021/..

5

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors:

Veenstra, Siem Jakob ; Rueeger, Heinrich ; Voegtle, Markus...
Bioorganic & Medicinal Chemistry Letters. 28 (2018) 12 - p. 2195-2200 , 2018

Link: https://doi.org/10.1016/..

6

TheBACE‐1 inhibitorCNP520 for prevention trials in Alzheime..:

Neumann, Ulf ; Ufer, Mike ; Jacobson, Laura H...
EMBO Molecular Medicine. 10 (2018) 11 - p. , 2018

Link: https://doi.org/10.15252..

7

A novel BACE inhibitor NB-360 shows a superior pharmacologi..:

Neumann, Ulf ; Rueeger, Heinrich ; Machauer, Rainer...
Molecular Neurodegeneration. 10 (2015) 1 - p. , 2015

Link: https://doi.org/10.1186/..

8

P4‐363: THE BACE INHIBITOR NB‐360 HAS EXCELLENT BRAIN PENET..:

Neumann, Ulf ; Rueeger, Heinrich ; Machauer, Rainer...
Alzheimer's & Dementia. 10 (2014) 4S_Part_16 - p. , 2014

Link: https://doi.org/10.1016/..

9

Discovery of cyclic sulfoxide hydroxyethylamines as potent ..:

Rueeger, Heinrich ; Lueoend, Rainer ; Machauer, Rainer...
Bioorganic & Medicinal Chemistry Letters. 23 (2013) 19 - p. 5300-5306 , 2013

Link: https://doi.org/10.1016/..

10

Discovery of Cyclic Sulfone Hydroxyethylamines as Potent an..:

Rueeger, Heinrich ; Lueoend, Rainer ; Rogel, Olivier...
Journal of Medicinal Chemistry. 55 (2012) 7 - p. 3364-3386 , 2012

Link: https://doi.org/10.1021/..

11

Structure based design, synthesis and SAR of cyclic hydroxy..:

Rueeger, Heinrich ; Rondeau, Jean-Michel ; McCarthy, Clive...
Bioorganic & Medicinal Chemistry Letters. 21 (2011) 7 - p. 1942-1947 , 2011

Link: https://doi.org/10.1016/..

12

Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain af..:

Lerchner, Andreas ; Machauer, Rainer ; Betschart, Claudia...
Bioorganic & Medicinal Chemistry Letters. 20 (2010) 2 - p. 603-607 , 2010

Link: https://doi.org/10.1016/..

13

Signal peptide peptidase dependent cleavage of type II tran..:

Dev, Kumlesh K. ; Chatterjee, Sandipan ; Osinde, Maribel...
European Journal of Pharmacology. 540 (2006) 1-3 - p. 10-17 , 2006

Link: https://doi.org/10.1016/..

14

Discovery and SAR of potent, orally available and brain-pen..:

Rueeger, Heinrich ; Gerspacher, Marc ; Buehlmayer, Peter...
Bioorganic & Medicinal Chemistry Letters. 14 (2004) 10 - p. 2451-2457 , 2004

Link: https://doi.org/10.1016/..

15

P2-064 Rapid Aβ turnover and reduction of amyloid plaque fo..:

Abramowski, Dorothee ; Holloway, Robert ; Wiederhold, Karl-Heinz...
Neurobiology of Aging. 25 (2004) - p. S242 , 2004

Link: https://doi.org/10.1016/..