E-LIB Suche - Ergebnisse für: Smith, Christopher R.

1

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demo..:

Sudhakar, Niranjan ; Yan, Larry ; Qiryaqos, Fadia...
Molecular Cancer Therapeutics. , 2024

2

Discovery of Pyridopyrimidinones that Selectively Inhibit t..:

Ketcham, John M. ; Harwood, Stephen J. ; Aranda, Ruth...
Journal of Medicinal Chemistry. 67 (2024) 6 - p. 4936-4949 , 2024

Link: https://doi.org/10.1021/..

3

Stereoselective Amine Synthesis Mediated by a Zirconocene H..:

Aloiau, Athenea N. ; Bobek, Briana M. ; Caddell Haatveit, Kersti...
The Journal of Organic Chemistry. 89 (2024) 6 - p. 3875-3882 , 2024

Link: https://doi.org/10.1021/..

4

Discovery of Five SOS2 Fragment Hits with Binding Modes Det..:

Smith, Christopher R. ; Chen, Dan ; Christensen, James G....
Journal of Medicinal Chemistry. 67 (2023) 1 - p. 774-781 , 2023

Link: https://doi.org/10.1021/..

5

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibit..:

Engstrom, Lars D. ; Aranda, Ruth ; Waters, Laura...
Cancer Discovery. 13 (2023) 11 - p. 2412-2431 , 2023

Link: https://doi.org/10.1158/..

6

Selected Approaches to Disrupting Protein–Protein Interacti..:

Harwood, Stephen J. ; Smith, Christopher R. ; Lawson, J. David.
International Journal of Molecular Sciences. 24 (2023) 8 - p. 7373 , 2023

Link: https://doi.org/10.3390/..

7

Fragment optimization and elaboration strategies – the disc..:

Smith, Christopher R. ; Kulyk, Svitlana ; Ahmad, Misbha Ud Din...
RSC Medicinal Chemistry. 13 (2022) 12 - p. 1549-1564 , 2022

Link: https://doi.org/10.1039/..

8

Design and evaluation of achiral, non-atropisomeric 4-(amin..:

Smith, Christopher R. ; Aranda, Ruth ; Christensen, James G....
Bioorganic & Medicinal Chemistry. 71 (2022) - p. 116947 , 2022

Link: https://doi.org/10.1016/..

9

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal In..:

Smith, Christopher R. ; Aranda, Ruth ; Bobinski, Thomas P....
Journal of Medicinal Chemistry. 65 (2022) 3 - p. 1749-1766 , 2022

Link: https://doi.org/10.1021/..

10

Design and Discovery of MRTX0902, a Potent, Selective, Brai..:

Ketcham, John M. ; Haling, Jacob ; Khare, Shilpi...
Journal of Medicinal Chemistry. 65 (2022) 14 - p. 9678-9690 , 2022

Link: https://doi.org/10.1021/..

11

Atropisomeric Racemization Kinetics of MRTX1719 Using Chira..:

Kulyk, Svitlana ; De Paul, Susan M. ; Marx, Matthew A...
ACS Omega. 7 (2022) 36 - p. 32062-32067 , 2022

Link: https://doi.org/10.1021/..

12

Anti-tumor efficacy of a potent and selective non-covalent ..:

Hallin, Jill ; Bowcut, Vickie ; Calinisan, Andrew...
Nature Medicine. 28 (2022) 10 - p. 2171-2182 , 2022

Link: https://doi.org/10.1038/..

13

Correction to "Discovery of the Bruton's Tyrosine Kinase In..:

Sabat, Mark ; Dougan, Douglas R ; Ermolieff, Jacques...
Journal of Medicinal Chemistry. 64 (2021) 21 - p. 16318-16318 , 2021

Link: https://doi.org/10.1021/..

14

Selective patterning of out-of-plane piezoelectricity in Mo..:

Seol, Daehee ; Kim, Songkil ; Jang, Woo-Sung...
Nano Energy. 79 (2021) - p. 105451 , 2021

Link: https://doi.org/10.1016/..

15

Identification of MRTX1133, a Noncovalent, Potent, and Sele..:

Wang, Xiaolun ; Allen, Shelley ; Blake, James F....
Journal of Medicinal Chemistry. 65 (2021) 4 - p. 3123-3133 , 2021

Link: https://doi.org/10.1021/..