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Eigenbrot, Charles
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1

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhi..:

Hanan, Emily J. ; Braun, Marie-Gabrielle ; Heald, Robert A....
Journal of Medicinal Chemistry.  65 (2022)  24 - p. 16589-16621 , 2022
Link: https://doi.org/10.1021/..
 
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2

Structure-based optimization of hydroxylactam as potent, ce..:

Wei, BinQing ; Robarge, Kirk ; Labadie, Sharada S....
Bioorganic & Medicinal Chemistry Letters.  59 (2022)  - p. 128576 , 2022
Link: https://doi.org/10.1016/..
 
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3

Structures of the ApoL1 and ApoL2 N-terminal domains reveal..:

Ultsch, Mark ; Holliday, Michael J. ; Gerhardy, Stefan...
Communications Biology.  4 (2021)  1 - p. , 2021
Link: https://doi.org/10.1038/..
 
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4

Targeting KRAS Mutant Cancers via Combination Treatment: Di..:

Huestis, Malcolm P. ; Durk, Matthew R. ; Eigenbrot, Charles...
ACS Medicinal Chemistry Letters.  12 (2021)  5 - p. 791-797 , 2021
Link: https://doi.org/10.1021/..
 
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5

Targeting KRAS Mutant Cancers via Combination Treatment: Di..:

Huestis, Malcolm P. ; Dela Cruz, Darlene ; DiPasquale, Antonio G....
Journal of Medicinal Chemistry.  64 (2021)  7 - p. 3940-3955 , 2021
Link: https://doi.org/10.1021/..
 
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6

Stereochemical Differences in Fluorocyclopropyl Amides Enab..:

Crawford, James J. ; Lee, Wendy ; Johnson, Adam R....
ACS Medicinal Chemistry Letters.  11 (2020)  8 - p. 1588-1597 , 2020
Link: https://doi.org/10.1021/..
 
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7

Bivalent antibody pliers inhibit β-tryptase by an allosteri..:

Maun, Henry R. ; Vij, Rajesh ; Walters, Benjamin T....
Nature Communications.  11 (2020)  1 - p. , 2020
Link: https://doi.org/10.1038/..
 
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8

Design of Organo-Peptides As Bipartite PCSK9 Antagonists:

Burdick, Daniel J. ; Skelton, Nicholas J. ; Ultsch, Mark...
ACS Chemical Biology.  15 (2020)  2 - p. 425-436 , 2020
Link: https://doi.org/10.1021/..
 
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9

Water molecules in protein–ligand interfaces. Evaluation of..:

Nittinger, Eva ; Gibbons, Paul ; Eigenbrot, Charles...
Journal of Computer-Aided Molecular Design.  33 (2019)  3 - p. 307-330 , 2019
Link: https://doi.org/10.1007/..
 
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10

Potent and selective inhibitors of receptor-interacting pro..:

Hamilton, Gregory L. ; Chen, Huifen ; Deshmukh, Gauri...
Bioorganic & Medicinal Chemistry Letters.  29 (2019)  12 - p. 1497-1501 , 2019
Link: https://doi.org/10.1016/..
 
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11

Dual functionality of β-tryptase protomers as both protease..:

Maun, Henry R. ; Liu, Peter S. ; Franke, Yvonne...
Journal of Biological Chemistry.  293 (2018)  25 - p. 9614-9628 , 2018
Link: https://doi.org/10.1074/..
 
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12

Discovery of GDC-0853: A Potent, Selective, and Noncovalent..:

Crawford, James J. ; Johnson, Adam R. ; Misner, Dinah L....
Journal of Medicinal Chemistry.  61 (2018)  6 - p. 2227-2245 , 2018
Link: https://doi.org/10.1021/..
 
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13

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers..:

Wei, BinQing ; Gunzner-Toste, Janet ; Yao, Hui...
Journal of Medicinal Chemistry.  61 (2017)  3 - p. 989-1000 , 2017
Link: https://doi.org/10.1021/..
 
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14

Identification of an imidazopyridine scaffold to generate p..:

Liang, Jun ; Van Abbema, Anne ; Balazs, Mercedesz...
Bioorganic & Medicinal Chemistry Letters.  27 (2017)  18 - p. 4370-4376 , 2017
Link: https://doi.org/10.1016/..
 
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15

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (..:

Castanedo, Georgette M. ; Blaquiere, Nicole ; Beresini, Maureen...
Journal of Medicinal Chemistry.  60 (2017)  2 - p. 627-640 , 2017
Link: https://doi.org/10.1021/..
 
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