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Goldberg, Frederick W.
794
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1
Metabolism-driven in vitro/in vivo disconnect of an oral ER..:
Hayhow, Thomas G.
;
Williamson, Beth
;
Lawson, Mandy
...
Communications Biology. 7 (2024) 1 - p. , 2024
Link:
https://doi.org/10.1038/..
?
2
α‐Functionalisation of Cyclic Sulfides Enabled by Lithiatio..:
Seling, Nico
;
Atobe, Masakazu
;
Kasten, Kevin
...
Angewandte Chemie International Edition. 63 (2023) 2 - p. , 2023
Link:
https://doi.org/10.1002/..
?
3
α‐Functionalisation of Cyclic Sulfides Enabled by Lithiatio..:
Seling, Nico
;
Atobe, Masakazu
;
Kasten, Kevin
...
Angewandte Chemie. 136 (2023) 2 - p. , 2023
Link:
https://doi.org/10.1002/..
?
4
Chemical Biology Approaches Confirm MCT4 as the Therapeutic..:
Kawatkar, Aarti
;
Clark, Roger A.
;
Hopcroft, Lorna
...
ACS Chemical Biology. 18 (2023) 2 - p. 296-303 , 2023
Link:
https://doi.org/10.1021/..
?
5
Optimization of a series of novel, potent and selective Mac..:
Grimster, Neil P.
;
Gingipalli, Lakshmaiah
;
Balazs, Amber
...
Bioorganic & Medicinal Chemistry Letters. 91 (2023) - p. 129352 , 2023
Link:
https://doi.org/10.1016/..
?
6
Discovery of AZD4747, a Potent and Selective Inhibitor of M..:
Kettle, Jason G.
;
Bagal, Sharan K.
;
Barratt, Derek
...
Journal of Medicinal Chemistry. 66 (2023) 13 - p. 9147-9160 , 2023
Link:
https://doi.org/10.1021/..
?
7
Direct targeting of FOXP3 in Tregs with AZD8701, a novel an..:
Revenko, Alexey
;
Carnevalli, Larissa S
;
Sinclair, Charles
...
Journal for ImmunoTherapy of Cancer. 10 (2022) 4 - p. e003892 , 2022
Link:
https://doi.org/10.1136/..
?
8
Discovery of AZD4625, a Covalent Allosteric Inhibitor of th..:
Kettle, Jason G.
;
Bagal, Sharan K.
;
Bickerton, Sue
...
Journal of Medicinal Chemistry. 65 (2022) 9 - p. 6940-6952 , 2022
Link:
https://doi.org/10.1021/..
?
9
Discovery of Clinical Candidate AZD0095, a Selective Inhibi..:
Goldberg, Frederick W.
;
Kettle, Jason G.
;
Lamont, Gillian M.
...
Journal of Medicinal Chemistry. 66 (2022) 1 - p. 384-397 , 2022
Link:
https://doi.org/10.1021/..
?
10
Optimization of hERG and Pharmacokinetic Properties for Bas..:
Goldberg, Frederick W.
;
Ting, Attilla K. T.
;
Beattie, David
...
ACS Medicinal Chemistry Letters. 13 (2022) 8 - p. 1295-1301 , 2022
Link:
https://doi.org/10.1021/..
?
11
Structure-Based Design and Pharmacokinetic Optimization of ..:
Kettle, Jason G.
;
Bagal, Sharan K.
;
Bickerton, Sue
...
Journal of Medicinal Chemistry. 63 (2020) 9 - p. 4468-4483 , 2020
Link:
https://doi.org/10.1021/..
?
12
Optimization of a series of potent, selective and orally bi..:
Grimster, Neil P.
;
Gingipalli, Lakshmaiah
;
Barlaam, Bernard
...
Bioorganic & Medicinal Chemistry Letters. 30 (2020) 19 - p. 127433 , 2020
Link:
https://doi.org/10.1016/..
?
13
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a..:
Goldberg, Frederick W.
;
Finlay, M. Raymond V.
;
Ting, Attilla K. T.
...
Journal of Medicinal Chemistry. 63 (2019) 7 - p. 3461-3471 , 2019
Link:
https://doi.org/10.1021/..
?
14
AZD7648 is a potent and selective DNA-PK inhibitor that enh..:
Fok, Jacqueline H. L.
;
Ramos-Montoya, Antonio
;
Vazquez-Chantada, Mercedes
...
Nature Communications. 10 (2019) 1 - p. , 2019
Link:
https://doi.org/10.1038/..
?
15
Evolution of Small Molecule Kinase Drugs:
Lightfoot, Helen L.
;
Goldberg, Frederick W.
;
Sedelmeier, Joerg
ACS Medicinal Chemistry Letters. 10 (2018) 2 - p. 153-160 , 2018
Link:
https://doi.org/10.1021/..
1-15