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Appleby, Todd
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1

Evaluation of Free Energy Calculations for the Prioritizati..:

Paulsen, Janet L. ; Yu, Haoyu S. ; Sindhikara, Dan...
Journal of Chemical Information and Modeling.  60 (2020)  7 - p. 3489-3498 , 2020
Link: https://doi.org/10.1021/..
 
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2

Discovery of GS-9688 (Selgantolimod) as a Potent and Select..:

Mackman, Richard L. ; Mish, Michael ; Chin, Gregory...
Journal of Medicinal Chemistry.  63 (2020)  18 - p. 10188-10203 , 2020
Link: https://doi.org/10.1021/..
 
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3

Discovery of the pan-genotypic hepatitis C virus NS3/4A pro..:

Taylor, James G. ; Zipfel, Sheila ; Ramey, Kyla...
Bioorganic & Medicinal Chemistry Letters.  29 (2019)  16 - p. 2428-2436 , 2019
Link: https://doi.org/10.1016/..
 
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4

Discovery of a Potent and Orally Bioavailable Cyclophilin I..:

Mackman, Richard L. ; Steadman, Victoria A. ; Dean, David K....
Journal of Medicinal Chemistry.  61 (2018)  21 - p. 9473-9499 , 2018
Link: https://doi.org/10.1021/..
 
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5

Structural and Regulatory Elements of HCV NS5B Polymerase –..:

Boyce, Sarah E. ; Tirunagari, Neeraj ; Niedziela-Majka, Anita...
PLoS ONE.  9 (2014)  1 - p. e84808 , 2014
Link: https://doi.org/10.1371/..
 
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6

Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibi..:

Lazerwith, Scott E. ; Lew, Willard ; Zhang, Jennifer...
Journal of Medicinal Chemistry.  57 (2013)  5 - p. 1893-1901 , 2013
Link: https://doi.org/10.1021/..
 
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7

Discovery of GS-9451: An acid inhibitor of the hepatitis C ..:

Christopher Sheng, X. ; Appleby, Todd ; Butler, Thomas...
Bioorganic & Medicinal Chemistry Letters.  22 (2012)  7 - p. 2629-2634 , 2012
Link: https://doi.org/10.1016/..
 
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8

Tri-substituted acylhydrazines as tertiary amide bioisoster..:

Canales, Eda ; Carlson, Joseph S. ; Appleby, Todd...
Bioorganic & Medicinal Chemistry Letters.  22 (2012)  13 - p. 4288-4292 , 2012
Link: https://doi.org/10.1016/..
 
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9

Novel thiazolones as HCV NS5B polymerase allosteric inhibit..:

Yan, Shunqi ; Larson, Gary ; Wu, Jim Z....
Bioorganic & Medicinal Chemistry Letters.  17 (2007)  1 - p. 63-67 , 2007
Link: https://doi.org/10.1016/..
 
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10

Identification and structure–activity relationships of subs..:

Cheney, I. Wayne ; Yan, Shunqi ; Appleby, Todd...
Bioorganic & Medicinal Chemistry Letters.  17 (2007)  6 - p. 1679-1683 , 2007
Link: https://doi.org/10.1016/..
 
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11

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase al..:

Yan, Shunqi ; Appleby, Todd ; Larson, Gary...
Bioorganic & Medicinal Chemistry Letters.  17 (2007)  7 - p. 1991-1995 , 2007
Link: https://doi.org/10.1016/..
 
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12

Isothiazoles as active-site inhibitors of HCV NS5B polymera..:

Yan, Shunqi ; Appleby, Todd ; Gunic, Esmir...
Bioorganic & Medicinal Chemistry Letters.  17 (2007)  1 - p. 28-33 , 2007
Link: https://doi.org/10.1016/..
 
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13

Structure-based design of a novel thiazolone scaffold as HC..:

Yan, Shunqi ; Appleby, Todd ; Larson, Gary...
Bioorganic & Medicinal Chemistry Letters.  16 (2006)  22 - p. 5888-5891 , 2006
Link: https://doi.org/10.1016/..
 
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14

Identification of isothiazole-4-carboxamidines derivatives ..:

El Abdellaoui, Hassan ; Varaprasad, Chamakura V.N.S. ; Barawkar, Dinesh...
Bioorganic & Medicinal Chemistry Letters.  16 (2006)  21 - p. 5561-5566 , 2006
Link: https://doi.org/10.1016/..
 
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15

Protein crystallography using a multilayer monochromator:

Deacon, Ashley M. ; Appleby, Todd ; Bilderback, Donald H....
Journal of Synchrotron Radiation.  5 (1998)  3 - p. 494-496 , 1998
Link: https://doi.org/10.1107/..
 
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