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Bechle, Bruce M.
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1

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor..:

Allerton, Charlotte M. N. ; Arcari, Joel T. ; Aschenbrenner, Lisa M....
Journal of Medicinal Chemistry.  , 2024
Link: https://doi.org/10.1021/..
 
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2

Development of a scalable synthetic route towards a 2,2,6-t..:

Huh, Chan Woo ; Bechle, Bruce M. ; Warmus, Joseph S.
Tetrahedron Letters.  59 (2018)  19 - p. 1808-1812 , 2018
Link: https://doi.org/10.1016/..
 
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3

Discovery of Potent, Selective, and Peripherally Restricted..:

Bagal, Sharan K. ; Andrews, Mark ; Bechle, Bruce M....
Journal of Medicinal Chemistry.  61 (2018)  15 - p. 6779-6800 , 2018
Link: https://doi.org/10.1021/..
 
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4

One-Pot Synthesis of α-Branched N-Acylamines via Titanium-M..:

Dai, Chunhui ; Genovino, Julien ; Bechle, Bruce M....
Organic Letters.  19 (2017)  5 - p. 1064-1067 , 2017
Link: https://doi.org/10.1021/..
 
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5

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-..:

Swain, Nigel. A. ; Batchelor, Dave ; Beaudoin, Serge...
Journal of Medicinal Chemistry.  60 (2017)  16 - p. 7029-7042 , 2017
Link: https://doi.org/10.1021/..
 
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6

Highly potent and selective NaV1.7 inhibitors for use as in..:

Storer, R. Ian ; Pike, Andy ; Swain, Nigel A....
Bioorganic & Medicinal Chemistry Letters.  27 (2017)  21 - p. 4805-4811 , 2017
Link: https://doi.org/10.1016/..
 
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7

Diastereoselective Synthesis of β-Heteroaryl syn-α-Methyl-β..:

Bian, Jianwei ; Blakemore, David ; Warmus, Joseph S....
Organic Letters.  15 (2013)  3 - p. 562-565 , 2013
Link: https://doi.org/10.1021/..
 
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8

PF-04859989 as a template for structure-based drug design: ..:

Dounay, Amy B. ; Anderson, Marie ; Bechle, Bruce M....
Bioorganic & Medicinal Chemistry Letters.  23 (2013)  7 - p. 1961-1966 , 2013
Link: https://doi.org/10.1016/..
 
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9

Discovery of hydroxamate bioisosteres as KAT II inhibitors ..:

Henderson, Jaclyn L. ; Sawant-Basak, Aarti ; Tuttle, Jamison B....
MedChemComm.  4 (2013)  1 - p. 125-129 , 2013
Link: https://doi.org/10.1039/..
 
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10

Structure-Based Design of Irreversible Human KAT II Inhibit..:

Tuttle, Jamison B. ; Anderson, Marie ; Bechle, Bruce M....
ACS Medicinal Chemistry Letters.  4 (2012)  1 - p. 37-40 , 2012
Link: https://doi.org/10.1021/..
 
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11

Discovery of Brain-Penetrant, Irreversible Kynurenine Amino..:

Dounay, Amy B. ; Anderson, Marie ; Bechle, Bruce M....
ACS Medicinal Chemistry Letters.  3 (2012)  3 - p. 187-192 , 2012
Link: https://doi.org/10.1021/..
 
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12

A General Strategy for the Synthesis of Cyclic N-Aryl Hydro..:

McAllister, Laura A. ; Bechle, Bruce M. ; Dounay, Amy B....
The Journal of Organic Chemistry.  76 (2011)  9 - p. 3484-3497 , 2011
Link: https://doi.org/10.1021/..
 
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13

Synthesis of ortho-substituted nitroaromatics via improved ..:

Tuttle, Jamison B. ; Azzarelli, Joseph M. ; Bechle, Bruce M....
Tetrahedron Letters.  52 (2011)  41 - p. 5211-5213 , 2011
Link: https://doi.org/10.1016/..
 
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14

Discovery Tactics To Mitigate Toxicity Risks Due to Reactiv..:

Kalgutkar, Amit S. ; Griffith, David A. ; Ryder, Tim...
Chemical Research in Toxicology.  23 (2010)  6 - p. 1115-1126 , 2010
Link: https://doi.org/10.1021/..
 
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15

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones a..:

Humphries, Paul S. ; Benbow, John W. ; Bonin, Paul D....
Bioorganic & Medicinal Chemistry Letters.  19 (2009)  9 - p. 2400-2403 , 2009
Link: https://doi.org/10.1016/..
 
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