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Chandrasekhar, Jayaraman
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1

Enhanced utility of AI/ML methods during lead optimization ..:

Bleicher, Leo S. ; van Daelen, Ton ; Honeycutt, J. Dana...
Frontiers in Drug Discovery.  2 (2022)  - p. , 2022
Link: https://doi.org/10.3389/..
 
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2

Atropisomerism in Drug Discovery: A Medicinal Chemistry Per..:

Perreault, Stephane ; Chandrasekhar, Jayaraman ; Patel, Leena
Accounts of Chemical Research.  55 (2022)  18 - p. 2581-2593 , 2022
Link: https://doi.org/10.1021/..
 
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3

Discovery of an Atropisomeric PI3Kβ Selective Inhibitor thr..:

Perreault, Stephane ; Arjmand, Fatima ; Chandrasekhar, Jayaraman...
ACS Medicinal Chemistry Letters.  11 (2020)  6 - p. 1236-1243 , 2020
Link: https://doi.org/10.1021/..
 
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4

Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyr..:

Blomgren, Peter ; Chandrasekhar, Jayaraman ; Di Paolo, Julie A....
ACS Medicinal Chemistry Letters.  11 (2020)  4 - p. 506-513 , 2020
Link: https://doi.org/10.1021/..
 
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5

Atropisomerism by Design: Discovery of a Selective and Stab..:

Chandrasekhar, Jayaraman ; Dick, Ryan ; Van Veldhuizen, Joshua...
Journal of Medicinal Chemistry.  61 (2018)  15 - p. 6858-6868 , 2018
Link: https://doi.org/10.1021/..
 
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6

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibit..:

Perreault, Stephane ; Chandrasekhar, Jayaraman ; Cui, Zhi-Hua...
Journal of Medicinal Chemistry.  60 (2017)  4 - p. 1555-1567 , 2017
Link: https://doi.org/10.1021/..
 
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7

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Serie..:

Patel, Leena ; Chandrasekhar, Jayaraman ; Evarts, Jerry...
Journal of Medicinal Chemistry.  59 (2016)  7 - p. 3532-3548 , 2016
Link: https://doi.org/10.1021/..
 
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8

Selectivity switch between FAK and Pyk2: Macrocyclization o..:

Farand, Julie ; Mai, Nicholas ; Chandrasekhar, Jayaraman...
Bioorganic & Medicinal Chemistry Letters.  26 (2016)  24 - p. 5926-5930 , 2016
Link: https://doi.org/10.1016/..
 
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9

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ..:

Patel, Leena ; Chandrasekhar, Jayaraman ; Evarts, Jerry...
Journal of Medicinal Chemistry.  59 (2016)  19 - p. 9228-9242 , 2016
Link: https://doi.org/10.1021/..
 
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10

1-Benzylbenzimidazoles: The discovery of a novel series of ..:

Guo, Qin ; Chandrasekhar, Jayaraman ; Ihle, David...
Bioorganic & Medicinal Chemistry Letters.  18 (2008)  18 - p. 5027-5031 , 2008
Link: https://doi.org/10.1016/..
 
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11

The design, synthesis and structure–activity relationships ..:

Yoon, Taeyoung ; De Lombaert, Stéphane ; Brodbeck, Robbin...
Bioorganic & Medicinal Chemistry Letters.  18 (2008)  3 - p. 891-896 , 2008
Link: https://doi.org/10.1016/..
 
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12

Aminoquinazolines as TRPV1 antagonists: Modulation of drug-..:

Blum, Charles A. ; Zheng, Xiaozhang ; Brielmann, Harry...
Bioorganic & Medicinal Chemistry Letters.  18 (2008)  16 - p. 4573-4577 , 2008
Link: https://doi.org/10.1016/..
 
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13

2-Arylpyrimidines: Novel CRF-1 receptor antagonists:

Yoon, Taeyoung ; De Lombaert, Stéphane ; Brodbeck, Robbin...
Bioorganic & Medicinal Chemistry Letters.  18 (2008)  16 - p. 4486-4490 , 2008
Link: https://doi.org/10.1016/..
 
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14

From arylureas to biarylamides to aminoquinazolines: Discov..:

Zheng, Xiaozhang ; Hodgetts, Kevin J. ; Brielmann, Harry...
Bioorganic & Medicinal Chemistry Letters.  16 (2006)  19 - p. 5217-5221 , 2006
Link: https://doi.org/10.1016/..
 
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15

Investigation of Solvent Effects for the Claisen Rearrangem..:

Repasky, Matthew P. ; Guimarães, Cristiano Ruch Werneck ; Chandrasekhar, Jayaraman..
Journal of the American Chemical Society.  125 (2003)  22 - p. 6663-6672 , 2003
Link: https://doi.org/10.1021/..
 
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