E-LIB Suche - Ergebnisse für: Cheung, Kwai-Ming

1

A RIPK1-specific PROTAC degrader achieves potent antitumor ..:

Mannion, Jonathan ; Gifford, Valentina ; Bellenie, Benjamin...
Immunity. , 2024

Link: https://doi.org/10.1016/..

2

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition ..:

Harnden, Alice C. ; Davis, Owen A. ; Box, Gary M....
Journal of Medicinal Chemistry. 66 (2023) 8 - p. 5892-5906 , 2023

Link: https://doi.org/10.1021/..

3

Discovering cell-active BCL6 inhibitors: effectively combin..:

Pierrat, Olivier A. ; Liu, Manjuan ; Collie, Gavin W....
Scientific Reports. 12 (2022) 1 - p. , 2022

Link: https://doi.org/10.1038/..

4

Improved Binding Affinity and Pharmacokinetics Enable Susta..:

Huckvale, Rosemary ; Harnden, Alice C. ; Cheung, Kwai-Ming J....
Journal of Medicinal Chemistry. 65 (2022) 12 - p. 8191-8207 , 2022

Link: https://doi.org/10.1021/..

5

Optimizing Shape Complementarity Enables the Discovery of P..:

Davis, Owen A. ; Cheung, Kwai-Ming J. ; Brennan, Alfie...
Journal of Medicinal Chemistry. 65 (2022) 12 - p. 8169-8190 , 2022

Link: https://doi.org/10.1021/..

6

Into Deep Water: Optimizing BCL6 Inhibitors by Growing into..:

Lloyd, Matthew G. ; Huckvale, Rosemary ; Cheung, Kwai-Ming J....
Journal of Medicinal Chemistry. 64 (2021) 23 - p. 17079-17097 , 2021

Link: https://doi.org/10.1021/..

7

Achieving In Vivo Target Depletion through the Discovery an..:

Bellenie, Benjamin R. ; Cheung, Kwai-Ming J. ; Varela, Ana...
Journal of Medicinal Chemistry. 63 (2020) 8 - p. 4047-4068 , 2020

Link: https://doi.org/10.1021/..

8

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3..:

Woodward, Hannah L. ; Innocenti, Paolo ; Cheung, Kwai-Ming J....
Journal of Medicinal Chemistry. 61 (2018) 18 - p. 8226-8240 , 2018

Link: https://doi.org/10.1021/..

9

Multiparameter Lead Optimization to Give an Oral Checkpoint..:

Osborne, James D. ; Matthews, Thomas P. ; McHardy, Tatiana...
Journal of Medicinal Chemistry. 59 (2016) 11 - p. 5221-5237 , 2016

Link: https://doi.org/10.1021/..

10

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,..:

Naud, Sébastien ; Westwood, Isaac M. ; Faisal, Amir...
Journal of Medicinal Chemistry. 56 (2013) 24 - p. 10045-10065 , 2013

Link: https://doi.org/10.1021/..

11

Design of Potent and Selective Hybrid Inhibitors of the Mit..:

Innocenti, Paolo ; Cheung, Kwai-Ming J. ; Solanki, Savade...
Journal of Medicinal Chemistry. 55 (2012) 7 - p. 3228-3241 , 2012

Link: https://doi.org/10.1021/..

12

Structure-Guided Evolution of Potent and Selective CHK1 Inh..:

Reader, John C. ; Matthews, Thomas P. ; Klair, Suki...
Journal of Medicinal Chemistry. 54 (2011) 24 - p. 8328-8342 , 2011

Link: https://doi.org/10.1021/..

13

Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pip..:

McHardy, Tatiana ; Caldwell, John J. ; Cheung, Kwai-Ming...
Journal of Medicinal Chemistry. 53 (2010) 5 - p. 2239-2249 , 2010

Link: https://doi.org/10.1021/..

14

Aminopyrazine Inhibitors Binding to an Unusual Inactive Con..:

Whelligan, Daniel K. ; Solanki, Savade ; Taylor, Dawn...
Journal of Medicinal Chemistry. 53 (2010) 21 - p. 7682-7698 , 2010

Link: https://doi.org/10.1021/..

15

Identification of Inhibitors of Checkpoint Kinase 1 through..:

Matthews, Thomas P. ; Klair, Suki ; Burns, Samantha...
Journal of Medicinal Chemistry. 52 (2009) 15 - p. 4810-4819 , 2009

Link: https://doi.org/10.1021/..