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De Savi, Chris
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1

Discovery of BLU-945, a Reversible, Potent, and Wild-Type-S..:

Eno, Meredith S. ; Brubaker, Jason D. ; Campbell, John E....
Journal of Medicinal Chemistry.  65 (2022)  14 - p. 9662-9677 , 2022
Link: https://doi.org/10.1021/..
 
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2

Discovery of a Series of 7-Azaindoles as Potent and Highly ..:

Barlaam, Bernard ; De Savi, Chris ; Dishington, Allan...
Journal of Medicinal Chemistry.  64 (2021)  20 - p. 15189-15213 , 2021
Link: https://doi.org/10.1021/..
 
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3

Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal P..:

Hendricks, J. Adam ; Beaton, Nigel ; Chernobrovkin, Alexey...
ACS Chemical Biology.  17 (2021)  1 - p. 54-67 , 2021
Link: https://doi.org/10.1021/..
 
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4

Quest for a COVID-19 Cure by Repurposing Small-Molecule Dru..:

De Savi, Chris ; Hughes, David L. ; Kvaerno, Lisbet
Organic Process Research & Development.  24 (2020)  6 - p. 940-976 , 2020
Link: https://doi.org/10.1021/..
 
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5

Discovery of AZD4573, a Potent and Selective Inhibitor of C..:

Barlaam, Bernard ; Casella, Robert ; Cidado, Justin...
Journal of Medicinal Chemistry.  63 (2020)  24 - p. 15564-15590 , 2020
Link: https://doi.org/10.1021/..
 
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6

General methods for the synthesis and late-stage diversific..:

Varnes, Jeffrey G. ; McGuire, Thomas ; Meadows, Rebecca E....
Tetrahedron Letters.  57 (2016)  42 - p. 4718-4722 , 2016
Link: https://doi.org/10.1016/..
 
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7

Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chrom..:

Degorce, Sébastien L. ; Bailey, Andrew ; Callis, Rowena...
Journal of Medicinal Chemistry.  59 (2016)  7 - p. 3576-3576 , 2016
Link: https://doi.org/10.1021/..
 
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8

Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphe..:

Degorce, Sébastien L. ; Bailey, Andrew ; Callis, Rowena...
Journal of Medicinal Chemistry.  58 (2015)  8 - p. 3522-3533 , 2015
Link: https://doi.org/10.1021/..
 
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9

Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluor..:

De Savi, Chris ; Bradbury, Robert H. ; Rabow, Alfred A....
Journal of Medicinal Chemistry.  58 (2015)  20 - p. 8128-8140 , 2015
Link: https://doi.org/10.1021/..
 
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10

Efficacious Inhaled PDE4 Inhibitors with Low Emetic Potenti..:

De Savi, Chris ; Cox, Rhona J. ; Warner, Daniel J....
Journal of Medicinal Chemistry.  57 (2014)  11 - p. 4661-4676 , 2014
Link: https://doi.org/10.1021/..
 
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11

Hydantoin based inhibitors of MMP13—Discovery of AZD6605:

De Savi, Chris ; Waterson, David ; Pape, Andrew...
Bioorganic & Medicinal Chemistry Letters.  23 (2013)  16 - p. 4705-4712 , 2013
Link: https://doi.org/10.1016/..
 
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12

Lead optimisation of selective non-zinc binding inhibitors ..:

De Savi, Chris ; Morley, Andrew D. ; Nash, Ian...
Bioorganic & Medicinal Chemistry Letters.  22 (2012)  1 - p. 271-277 , 2012
Link: https://doi.org/10.1016/..
 
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13

Selective non zinc binding inhibitors of MMP13:

Savi, Chris De ; Morley, Andrew D. ; Ting, Attilla...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  14 - p. 4215-4219 , 2011
Link: https://doi.org/10.1016/..
 
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14

The design and synthesis of novel N-hydroxyformamide inhibi..:

De Savi, Chris ; Pape, Andrew ; Cumming, John G....
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  5 - p. 1376-1381 , 2011
Link: https://doi.org/10.1016/..
 
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15

Orally active achiral N-hydroxyformamide inhibitors of ADAM..:

De Savi, Chris ; Pape, Andrew ; Sawyer, Yvonne...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  11 - p. 3301-3306 , 2011
Link: https://doi.org/10.1016/..
 
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