E-LIB Suche - Ergebnisse für: Embrey, Kevin

1

Discovery and Optimization of the First ATP Competitive Typ..:

Michaelides, Iacovos N. ; Collie, Gavin W. ; Börjesson, Ulf...
Journal of Medicinal Chemistry. 66 (2023) 13 - p. 8782-8807 , 2023

Link: https://doi.org/10.1021/..

2

Design of rigid protein–protein interaction inhibitors enab..:

Hargreaves, David ; Carbajo, Rodrigo J. ; Bodnarchuk, Michael S....
Proceedings of the National Academy of Sciences. 120 (2023) 21 - p. , 2023

Link: https://doi.org/10.1073/..

3

Bromodomain Interactions with Acetylated Histone 4 Peptides..:

Wernersson, Sven ; Bobby, Romel ; Flavell, Liz...
Biochemistry. 61 (2022) 21 - p. 2303-2318 , 2022

Link: https://doi.org/10.1021/..

4

Fragment screening at AstraZeneca: developing the next gene..:

Lucas, Simon C. C. ; Börjesson, Ulf ; Bostock, Mark J....
RSC Medicinal Chemistry. 13 (2022) 9 - p. 1052-1057 , 2022

Link: https://doi.org/10.1039/..

5

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyri..:

Johannes, Jeffrey W. ; Balazs, Amber ; Barratt, Derek...
Journal of Medicinal Chemistry. 64 (2021) 19 - p. 14498-14512 , 2021

Link: https://doi.org/10.1021/..

6

Dynamics of the HD regulatory subdomain of PARP-1; substrat..:

Ogden, Tom E H ; Yang, Ji-Chun ; Schimpl, Marianne...
Nucleic Acids Research. 49 (2021) 4 - p. 2266-2288 , 2021

Link: https://doi.org/10.1093/..

7

Structural Basis for Targeting the Folded P-Loop Conformati..:

Collie, Gavin W. ; Michaelides, Iacovos N. ; Embrey, Kevin...
ACS Medicinal Chemistry Letters. 12 (2020) 1 - p. 162-167 , 2020

Link: https://doi.org/10.1021/..

8

Mapping Hidden Residual Structure within the Myc bHLH-LZ Do..:

Panova, Stanislava ; Cliff, Matthew J. ; Macek, Pavel...
Structure. 27 (2019) 10 - p. 1537-1546.e4 , 2019

Link: https://doi.org/10.1016/..

9

KRAS-specific inhibition using a DARPin binding to a site i..:

Bery, Nicolas ; Legg, Sandrine ; Debreczeni, Judit...
Nature Communications. 10 (2019) 1 - p. , 2019

Link: https://doi.org/10.1038/..

10

Biophysical methods in early drug discovery:

Holdgate, Geoffrey ; Embrey, Kevin ; Milbradt, Alexander.
ADMET and DMPK. 7 (2019) 4 - p. 222-241 , 2019

Link: https://doi.org/10.5599/..

11

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinic..:

Tron, Adriana E. ; Belmonte, Matthew A. ; Adam, Ammar...
Nature Communications. 9 (2018) 1 - p. , 2018

Link: https://doi.org/10.1038/..

12

Myc phosphorylation in its basic helix–loop–helix region de..:

Macek, Pavel ; Cliff, Matthew J. ; Embrey, Kevin J....
Journal of Biological Chemistry. 293 (2018) 24 - p. 9301-9310 , 2018

Link: https://doi.org/10.1074/..

13

Monitoring Ras Interactions with the Nucleotide Exchange Fa..:

Vo, Uybach ; Vajpai, Navratna ; Flavell, Liz...
Journal of Biological Chemistry. 291 (2016) 4 - p. 1703-1718 , 2016

Link: https://doi.org/10.1074/..

14

MTH1 Substrate Recognition—An Example of Specific Promiscui..:

Nissink, J. Willem M. ; Bista, Michal ; Breed, Jason...
PLOS ONE. 11 (2016) 3 - p. e0151154 , 2016

Link: https://doi.org/10.1371/..

15

Segmental Isotope Labelling of an Individual Bromodomain of..:

Williams, Felix P. ; Milbradt, Alexander G. ; Embrey, Kevin J...
PLOS ONE. 11 (2016) 4 - p. e0154607 , 2016

Link: https://doi.org/10.1371/..