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Florent Beaufils
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1

Investigation of morpholine isosters for the development of..:

De Pascale, Martina ; Bissegger, Lukas ; Tarantelli, Chiara...
European Journal of Medicinal Chemistry.  248 (2023)  - p. 115038 , 2023
Link: https://doi.org/10.1016/..
 
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2

4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-..:

Borsari, Chiara ; Keles, Erhan ; Rageot, Denise...
Journal of Medicinal Chemistry.  63 (2020)  22 - p. 13595-13617 , 2020
Link: https://doi.org/10.1021/..
 
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3

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor ..:

Singer, Elisabeth ; Walter, Carolin ; Fabbro, Doriano...
Neuropharmacology.  162 (2020)  - p. 107812 , 2020
Link: https://doi.org/10.1016/..
 
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4

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholi..:

Rageot, Denise ; Bohnacker, Thomas ; Keles, Erhan...
Journal of Medicinal Chemistry.  62 (2019)  13 - p. 6241-6261 , 2019
Link: https://doi.org/10.1021/..
 
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5

A Conformational Restriction Strategy for the Identificatio..:

Borsari, Chiara ; Rageot, Denise ; Dall'Asen, Alix...
Journal of Medicinal Chemistry.  62 (2019)  18 - p. 8609-8630 , 2019
Link: https://doi.org/10.1021/..
 
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6

Preclinical Development of PQR514, a Highly Potent PI3K Inh..:

Borsari, Chiara ; Rageot, Denise ; Beaufils, Florent...
ACS Medicinal Chemistry Letters.  10 (2019)  10 - p. 1473-1479 , 2019
Link: https://doi.org/10.1021/..
 
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7

Scalable, Economical, and Practical Synthesis of 4-(Difluor..:

Rageot, Denise ; Beaufils, Florent ; Borsari, Chiara...
Organic Process Research & Development.  23 (2019)  11 - p. 2416-2424 , 2019
Link: https://doi.org/10.1021/..
 
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8

The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Ac..:

Tarantelli, Chiara ; Gaudio, Eugenio ; Hillmann, Petra...
Cancers.  11 (2019)  6 - p. 775 , 2019
Link: https://doi.org/10.3390/..
 
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9

Discovery and Preclinical Characterization of 5-[4,6-Bis({3..:

Rageot, Denise ; Bohnacker, Thomas ; Melone, Anna...
Journal of Medicinal Chemistry.  61 (2018)  22 - p. 10084-10105 , 2018
Link: https://doi.org/10.1021/..
 
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10

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K..:

Brandt, Claudia ; Hillmann, Petra ; Noack, Andreas...
Neuropharmacology.  140 (2018)  - p. 107-120 , 2018
Link: https://doi.org/10.1016/..
 
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11

Deconvolution of Buparlisib's mechanism of action defines s..:

Bohnacker, Thomas ; Prota, Andrea E. ; Beaufils, Florent...
Nature Communications.  8 (2017)  1 - p. , 2017
Link: https://doi.org/10.1038/..
 
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12

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)..:

Beaufils, Florent ; Cmiljanovic, Natasa ; Cmiljanovic, Vladimir...
Journal of Medicinal Chemistry.  60 (2017)  17 - p. 7524-7538 , 2017
Link: https://doi.org/10.1021/..
 
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13

Cell‐Permeant and Photocleavable Chemical Inducer of Dimeri..:

Zimmermann, Mirjam ; Cal, Ruben ; Janett, Elia...
Angewandte Chemie International Edition.  53 (2014)  18 - p. 4717-4720 , 2014
Link: https://doi.org/10.1002/..
 
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14

Ein zellpermeables und photospaltbares Reagens für die sele..:

Zimmermann, Mirjam ; Cal, Ruben ; Janett, Elia...
Angewandte Chemie.  126 (2014)  18 - p. 4808-4812 , 2014
Link: https://doi.org/10.1002/..
 
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15

Chemical Development of Intracellular Protein Heterodimeriz..:

Erhart, Dominik ; Zimmermann, Mirjam ; Jacques, Olivier...
Chemistry & Biology.  20 (2013)  4 - p. 549-557 , 2013
Link: https://doi.org/10.1016/..
 
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