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Fradera, Xavier
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1

Oxetane Promise Delivered: Discovery of Long-Acting IDO1 In..:

Li, Derun ; Sloman, David L. ; Achab, Abdelghani...
Journal of Medicinal Chemistry.  65 (2022)  8 - p. 6001-6016 , 2022
Link: https://doi.org/10.1021/..
 
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2

NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes:

Fradera, Xavier ; Reutershan, Michael H. ; Machacek, Michelle R...
ChemBioChem.  23 (2022)  6 - p. , 2022
Link: https://doi.org/10.1002/..
 
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3

Diminishing GSH-Adduct Formation of Tricyclic Diazepine-bas..:

Huang, Chunhui ; Fischer, Christian ; Machacek, Michelle R....
ACS Medicinal Chemistry Letters.  13 (2022)  4 - p. 734-741 , 2022
Link: https://doi.org/10.1021/..
 
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4

Projected Dose Optimization of Amino- and Hydroxypyrrolidin..:

Methot, Joey L. ; Zhou, Hua ; McGowan, Meredeth A....
Journal of Medicinal Chemistry.  64 (2021)  8 - p. 5137-5156 , 2021
Link: https://doi.org/10.1021/..
 
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5

Identification of Potent Reverse Indazole Inhibitors for HP..:

Yu, Elsie C. ; Methot, Joey L. ; Fradera, Xavier...
ACS Medicinal Chemistry Letters.  12 (2021)  3 - p. 459-466 , 2021
Link: https://doi.org/10.1021/..
 
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6

Structural insights on ligand recognition at the human leuk..:

Michaelian, Nairie ; Sadybekov, Anastasiia ; Besserer-Offroy, Élie...
Nature Communications.  12 (2021)  1 - p. , 2021
Link: https://doi.org/10.1038/..
 
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7

SAR towards indoline and 3-azaindoline classes of IDO1 inhi..:

Yu, Wensheng ; Deng, Yongqi ; Hopkins, Brett...
Bioorganic & Medicinal Chemistry Letters.  47 (2021)  - p. 128214 , 2021
Link: https://doi.org/10.1016/..
 
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8

Discovery of IDO1 inhibitors containing a decahydroquinolin..:

Yu, Wensheng ; Deng, Yongqi ; Sloman, David...
Bioorganic & Medicinal Chemistry Letters.  49 (2021)  - p. 128314 , 2021
Link: https://doi.org/10.1016/..
 
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9

Development of High-Throughput Assays for Evaluation of Hem..:

Lacey, Brian M. ; Xu, Zangwei ; Chai, Xiaomei...
SLAS Discovery.  26 (2021)  1 - p. 88-99 , 2021
Link: https://doi.org/10.1177/..
 
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10

Utilization of Metabolite Identification and Structural Dat..:

Hopkins, Brett ; Zhang, Hongjun ; Bharathan, Indu...
ACS Medicinal Chemistry Letters.  12 (2021)  9 - p. 1435-1440 , 2021
Link: https://doi.org/10.1021/..
 
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11

Discovery of a new series of PI3K-δ inhibitors from Virtual..:

Fradera, Xavier ; Deng, Qiaolin ; Achab, Abdelganhi...
Bioorganic & Medicinal Chemistry Letters.  42 (2021)  - p. 128046 , 2021
Link: https://doi.org/10.1016/..
 
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12

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors ..:

Vara, Brandon A. ; Levi, Samuel M. ; Achab, Abdelghani...
ACS Medicinal Chemistry Letters.  12 (2021)  4 - p. 653-661 , 2021
Link: https://doi.org/10.1021/..
 
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13

Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p5..:

Reutershan, Michael H. ; Machacek, Michelle R. ; Altman, Michael D....
Journal of Medicinal Chemistry.  64 (2021)  21 - p. 16213-16241 , 2021
Link: https://doi.org/10.1021/..
 
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14

Carbamate andN-Pyrimidine Mitigate Amide Hydrolysis: Struct..:

Li, Derun ; Deng, Yongqi ; Achab, Abdelghani...
ACS Medicinal Chemistry Letters.  12 (2021)  3 - p. 389-396 , 2021
Link: https://doi.org/10.1021/..
 
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15

Corrigendum to "Design of selective PI3Kδ inhibitors using ..:

Fradera, Xavier ; Methot, Joey L. ; Achab, Abdelghani...
Bioorganic & Medicinal Chemistry Letters.  30 (2020)  16 - p. 127363 , 2020
Link: https://doi.org/10.1016/..
 
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