E-LIB Suche - Ergebnisse für: Goldberg, Frederick W.

1

Metabolism-driven in vitro/in vivo disconnect of an oral ER..:

Hayhow, Thomas G. ; Williamson, Beth ; Lawson, Mandy...
Communications Biology. 7 (2024) 1 - p. , 2024

2

Discovery of AZD4747, a Potent and Selective Inhibitor of M..:

Kettle, Jason G. ; Bagal, Sharan K. ; Barratt, Derek...
Journal of Medicinal Chemistry. 66 (2023) 13 - p. 9147-9160 , 2023

Link: https://doi.org/10.1021/..

3

α‐Functionalisation of Cyclic Sulfides Enabled by Lithiatio..:

Seling, Nico ; Atobe, Masakazu ; Kasten, Kevin...
Angewandte Chemie International Edition. 63 (2023) 2 - p. , 2023

Link: https://doi.org/10.1002/..

4

α‐Functionalisation of Cyclic Sulfides Enabled by Lithiatio..:

Seling, Nico ; Atobe, Masakazu ; Kasten, Kevin...
Angewandte Chemie. 136 (2023) 2 - p. , 2023

Link: https://doi.org/10.1002/..

5

Chemical Biology Approaches Confirm MCT4 as the Therapeutic..:

Kawatkar, Aarti ; Clark, Roger A. ; Hopcroft, Lorna...
ACS Chemical Biology. 18 (2023) 2 - p. 296-303 , 2023

Link: https://doi.org/10.1021/..

6

Optimization of a series of novel, potent and selective Mac..:

Grimster, Neil P. ; Gingipalli, Lakshmaiah ; Balazs, Amber...
Bioorganic & Medicinal Chemistry Letters. 91 (2023) - p. 129352 , 2023

Link: https://doi.org/10.1016/..

7

Optimization of hERG and Pharmacokinetic Properties for Bas..:

Goldberg, Frederick W. ; Ting, Attilla K. T. ; Beattie, David...
ACS Medicinal Chemistry Letters. 13 (2022) 8 - p. 1295-1301 , 2022

Link: https://doi.org/10.1021/..

8

Discovery of AZD4625, a Covalent Allosteric Inhibitor of th..:

Kettle, Jason G. ; Bagal, Sharan K. ; Bickerton, Sue...
Journal of Medicinal Chemistry. 65 (2022) 9 - p. 6940-6952 , 2022

Link: https://doi.org/10.1021/..

9

Discovery of Clinical Candidate AZD0095, a Selective Inhibi..:

Goldberg, Frederick W. ; Kettle, Jason G. ; Lamont, Gillian M....
Journal of Medicinal Chemistry. 66 (2022) 1 - p. 384-397 , 2022

Link: https://doi.org/10.1021/..

10

Direct targeting of FOXP3 in Tregs with AZD8701, a novel an..:

Revenko, Alexey ; Carnevalli, Larissa S ; Sinclair, Charles...
Journal for ImmunoTherapy of Cancer. 10 (2022) 4 - p. e003892 , 2022

Link: https://doi.org/10.1136/..

11

Optimization of a series of potent, selective and orally bi..:

Grimster, Neil P. ; Gingipalli, Lakshmaiah ; Barlaam, Bernard...
Bioorganic & Medicinal Chemistry Letters. 30 (2020) 19 - p. 127433 , 2020

Link: https://doi.org/10.1016/..

12

Structure-Based Design and Pharmacokinetic Optimization of ..:

Kettle, Jason G. ; Bagal, Sharan K. ; Bickerton, Sue...
Journal of Medicinal Chemistry. 63 (2020) 9 - p. 4468-4483 , 2020

Link: https://doi.org/10.1021/..

13

AZD7648 is a potent and selective DNA-PK inhibitor that enh..:

Fok, Jacqueline H. L. ; Ramos-Montoya, Antonio ; Vazquez-Chantada, Mercedes...
Nature Communications. 10 (2019) 1 - p. , 2019

Link: https://doi.org/10.1038/..

14

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a..:

Goldberg, Frederick W. ; Finlay, M. Raymond V. ; Ting, Attilla K. T....
Journal of Medicinal Chemistry. 63 (2019) 7 - p. 3461-3471 , 2019

Link: https://doi.org/10.1021/..

15

Evolution of Small Molecule Kinase Drugs:

Lightfoot, Helen L. ; Goldberg, Frederick W. ; Sedelmeier, Joerg
ACS Medicinal Chemistry Letters. 10 (2018) 2 - p. 153-160 , 2018

Link: https://doi.org/10.1021/..