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Holbrook, Mark
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1

Applying the CiPA approach to evaluate cardiac proarrhythmi..:

Delaunois, Annie ; Abernathy, Matthew ; Anderson, Warren D....
Clinical and Translational Science.  14 (2021)  3 - p. 1133-1146 , 2021
Link: https://doi.org/10.1111/..
 
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2

Strategies to encourage the adoption of social housing duri..:

Prior, Helen ; Holbrook, Mark
Journal of Pharmacological and Toxicological Methods.  108 (2021)  - p. 106959 , 2021
Link: https://doi.org/10.1016/..
 
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3

Opportunities for use of one species for longer-term toxico..:

Prior, Helen ; Baldrick, Paul ; Beken, Sonja...
Regulatory Toxicology and Pharmacology.  113 (2020)  - p. 104624 , 2020
Link: https://doi.org/10.1016/..
 
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4

Utilization of mechanistic modelling and simulation to anal..:

Polak, Sebastian ; Craven, Jeremy ; Abbasi, Mitra.
Journal of Pharmacological and Toxicological Methods.  105 (2020)  - p. 106816 , 2020
Link: https://doi.org/10.1016/..
 
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5

Better prediction of the local concentration–effect relatio..:

Polak, Sebastian ; Tylutki, Zofia ; Holbrook, Mark.
Drug Discovery Today.  24 (2019)  7 - p. 1344-1354 , 2019
Link: https://doi.org/10.1016/..
 
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6

General Principles for the Validation of Proarrhythmia Risk..:

Li, Zhihua ; Mirams, Gary R. ; Yoshinaga, Takashi...
Clinical Pharmacology & Therapeutics.  107 (2019)  1 - p. 102-111 , 2019
Link: https://doi.org/10.1002/..
 
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7

Bridging the gap from current practice towards wider applic..:

Holbrook, Mark
Toxicology Letters.  280 (2017)  - p. S24 , 2017
Link: https://doi.org/10.1016/..
 
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8

Measurement of hyper- and hypotension during repeated dose ..:

Niehoff, Marc O. ; Niggemann, Birgit ; Sternberg, Jan..
Journal of Pharmacological and Toxicological Methods.  70 (2014)  3 - p. 268-275 , 2014
Link: https://doi.org/10.1016/..
 
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9

Benchmarking Safety Pharmacology Society (SPS) community, p..:

Valentin, Jean-Pierre ; Bass, Alan ; Bialecki, Russell...
Journal of Pharmacological and Toxicological Methods.  70 (2014)  3 - p. 310 , 2014
Link: https://doi.org/10.1016/..
 
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10

Safety pharmacology investigations in toxicology studies: A..:

Authier, Simon ; Vargas, Hugo M. ; Curtis, Michael J...
Journal of Pharmacological and Toxicological Methods.  68 (2013)  1 - p. 44-51 , 2013
Link: https://doi.org/10.1016/..
 
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11

Pharmacokinetic–pharmacodynamic modelling of the effect of ..:

Watson, Kenny J. ; Gorczyca, William P. ; Umland, John...
Journal of Pharmacological and Toxicological Methods.  63 (2011)  3 - p. 304-313 , 2011
Link: https://doi.org/10.1016/..
 
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12

Translation of drug-induced QTc prolongation in early drug ..:

Dubois, Vincent F.S. ; Chain, Anne ; van der Graaf, Piet...
Journal of Pharmacological and Toxicological Methods.  64 (2011)  1 - p. e35 , 2011
Link: https://doi.org/10.1016/..
 
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13

Pyrimido[4,5-d]azepines as potent and selective 5-HT2C rece..:

Andrews, Mark D. ; Fish, Paul V. ; Blagg, Julian...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  9 - p. 2715-2720 , 2011
Link: https://doi.org/10.1016/..
 
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14

Use of Zebrafish in safety pharmacology:

Redfern, Will S. ; Winter, Matthew J. ; Waldron, Gareth...
Journal of Pharmacological and Toxicological Methods.  62 (2010)  2 - p. e22 , 2010
Link: https://doi.org/10.1016/..
 
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15

PK/PD Modelling: Validation and use of iterative developmen..:

Dewhurst, Mark ; Attkins, Neil ; Connaughton, Chantelle...
Journal of Pharmacological and Toxicological Methods.  62 (2010)  2 - p. e30 , 2010
Link: https://doi.org/10.1016/..
 
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