E-LIB Suche - Ergebnisse für: Hughes, Robert O.

1

ABC transporters: human disease and pharmacotherapeutic pot..:

Moore, Jonathan M. ; Bell, Eric L. ; Hughes, Robert O..
Trends in Molecular Medicine. 29 (2023) 2 - p. 152-172 , 2023

Link: https://doi.org/10.1016/..

2

Structural basis of SARM1 activation, substrate recognition..:

Shi, Yun ; Kerry, Philip S. ; Nanson, Jeffrey D....
Molecular Cell. 82 (2022) 9 - p. 1643-1659.e10 , 2022

Link: https://doi.org/10.1016/..

3

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− P..:

Hughes, Robert O. ; Bosanac, Todd ; Mao, Xianrong...
Cell Reports. 34 (2021) 1 - p. 108588 , 2021

Link: https://doi.org/10.1016/..

4

SARM1 is a metabolic sensor activated by an increased NMN/N..:

Figley, Matthew D. ; Gu, Weixi ; Nanson, Jeffrey D....
Neuron. 109 (2021) 7 - p. 1118-1136.e11 , 2021

Link: https://doi.org/10.1016/..

5

Discovery of a Series of Pyrazinone RORγ Antagonists and Id..:

Harcken, Christian ; Csengery, Johanna ; Turner, Michael...
ACS Medicinal Chemistry Letters. 12 (2021) 1 - p. 143-154 , 2021

Link: https://doi.org/10.1021/..

6

Pharmacological SARM1 inhibition protects axon structure an..:

Bosanac, Todd ; Hughes, Robert O ; Engber, Thomas...
Brain. 144 (2021) 10 - p. 3226-3238 , 2021

Link: https://doi.org/10.1093/..

7

Axons Matter: The Promise of Treating Neurodegenerative Dis..:

Krauss, Raul ; Bosanac, Todd ; Devraj, Rajesh..
Trends in Pharmacological Sciences. 41 (2020) 4 - p. 281-293 , 2020

Link: https://doi.org/10.1016/..

8

cADPR is a gene dosage-sensitive biomarker of SARM1 activit..:

Sasaki, Yo ; Engber, Thomas M. ; Hughes, Robert O....
Experimental Neurology. 329 (2020) - p. 113252 , 2020

Link: https://doi.org/10.1016/..

9

NAD+cleavage activity by animal and plant TIR domains in ce..:

Horsefield, Shane ; Burdett, Hayden ; Zhang, Xiaoxiao...
Science. 365 (2019) 6455 - p. 793-799 , 2019

Link: https://doi.org/10.1126/..

10

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibito..:

Schnute, Mark E. ; Benoit, Stephen E. ; Buchler, Ingrid P....
ACS Medicinal Chemistry Letters. 10 (2018) 1 - p. 80-85 , 2018

Link: https://doi.org/10.1021/..

11

Discovery of INCB10820/PF-4178903, a potent, selective, and..:

Zheng, Changsheng ; Cao, Ganfeng ; Xia, Michael...
Bioorganic & Medicinal Chemistry Letters. 21 (2011) 5 - p. 1442-1446 , 2011

Link: https://doi.org/10.1016/..

12

Discovery of INCB8761/PF-4136309, a Potent, Selective, and ..:

Xue, Chu-Biao ; Wang, Anlai ; Han, Qi...
ACS Medicinal Chemistry Letters. 2 (2011) 12 - p. 913-918 , 2011

Link: https://doi.org/10.1021/..

13

Design and synthesis of novel CCR2 antagonists: Investigati..:

Trujillo, John I. ; Huang, Wei ; Hughes, Robert O....
Bioorganic & Medicinal Chemistry Letters. 21 (2011) 6 - p. 1827-1831 , 2011

Link: https://doi.org/10.1016/..

14

Investigation of the pyrazinones as PDE5 inhibitors: Evalua..:

Hughes, Robert O. ; Maddux, Todd ; Joseph Rogier, D....
Bioorganic & Medicinal Chemistry Letters. 21 (2011) 21 - p. 6348-6352 , 2011

Link: https://doi.org/10.1016/..

15

Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetr..:

Hughes, Robert O. ; Rogier, D.J. ; Devraj, Rajesh...
Bioorganic & Medicinal Chemistry Letters. 21 (2011) 9 - p. 2626-2630 , 2011

Link: https://doi.org/10.1016/..