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Hurth, Konstanze
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1

Ligandability Assessment of IL-1β by Integrated Hit Identif..:

Vulpetti, Anna ; Rondeau, Jean-Michel ; Bellance, Marie-Hélène...
Journal of Medicinal Chemistry.  67 (2024)  10 - p. 8141-8160 , 2024
Link: https://doi.org/10.1021/..
 
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2

Discovery of a selective and biologically active low-molecu..:

Hommel, Ulrich ; Hurth, Konstanze ; Rondeau, Jean-Michel...
Nature Communications.  14 (2023)  1 - p. , 2023
Link: https://doi.org/10.1038/..
 
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3

Discovery of Umibecestat (CNP520): A Potent, Selective, and..:

Machauer, Rainer ; Lueoend, Rainer ; Hurth, Konstanze...
Journal of Medicinal Chemistry.  64 (2021)  20 - p. 15262-15279 , 2021
Link: https://doi.org/10.1021/..
 
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4

Synthesis of the Potent, Selective, and Efficacious β-Secre..:

Rueeger, Heinrich ; Lueoend, Rainer ; Machauer, Rainer...
Journal of Medicinal Chemistry.  64 (2021)  8 - p. 4677-4696 , 2021
Link: https://doi.org/10.1021/..
 
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5

TheBACE‐1 inhibitorCNP520 for prevention trials in Alzheime..:

Neumann, Ulf ; Ufer, Mike ; Jacobson, Laura H...
EMBO Molecular Medicine.  10 (2018)  11 - p. , 2018
Link: https://doi.org/10.15252..
 
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6

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors:

Veenstra, Siem Jakob ; Rueeger, Heinrich ; Voegtle, Markus...
Bioorganic & Medicinal Chemistry Letters.  28 (2018)  12 - p. 2195-2200 , 2018
Link: https://doi.org/10.1016/..
 
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7

AQW051, a novel, potent and selective α7 nicotinic ACh rece..:

Feuerbach, Dominik ; Pezous, Nicole ; Weiss, Markus...
British Journal of Pharmacology.  172 (2015)  5 - p. 1292-1304 , 2015
Link: https://doi.org/10.1111/..
 
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8

Regioselective nitration of 3-fluoro-2-substituted benzoic ..:

Hurth, Konstanze ; Jacquier, Sébastien ; Lehmann, Hansjörg.
Tetrahedron Letters.  56 (2015)  22 - p. 2860-2862 , 2015
Link: https://doi.org/10.1016/..
 
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9

Exploring subtype selectivity and metabolic stability of a ..:

Hintermann, Samuel ; Hurth, Konstanze ; Nozulak, Joachim...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  5 - p. 1523-1526 , 2011
Link: https://doi.org/10.1016/..
 
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10

Decahydroisoquinoline derivatives as novel non-peptidic, po..:

Troxler, Thomas ; Hurth, Konstanze ; Schuh, Karl-Heinrich...
Bioorganic & Medicinal Chemistry Letters.  20 (2010)  5 - p. 1728-1734 , 2010
Link: https://doi.org/10.1016/..
 
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11

Discovery of novel non-peptidic β-alanine piperazine amide ..:

Troxler, Thomas ; Hurth, Konstanze ; Mattes, Henri...
Bioorganic & Medicinal Chemistry Letters.  19 (2009)  5 - p. 1305-1309 , 2009
Link: https://doi.org/10.1016/..
 
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12

Gamma-lactams—A novel scaffold for highly potent and select..:

Enz, Albert ; Feuerbach, Dominik ; Frederiksen, Mathias U....
Bioorganic & Medicinal Chemistry Letters.  19 (2009)  5 - p. 1287-1291 , 2009
Link: https://doi.org/10.1016/..
 
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13

Ergoline derivatives as highly potent and selective antagon..:

Troxler, Thomas ; Enz, Albert ; Hoyer, Daniel...
Bioorganic & Medicinal Chemistry Letters.  18 (2008)  3 - p. 979-982 , 2008
Link: https://doi.org/10.1016/..
 
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14

Identification and SAR of potent and selective non-peptide ..:

Troxler, Thomas ; Hoyer, Daniel ; Langenegger, Daniel...
Bioorganic & Medicinal Chemistry Letters.  17 (2007)  14 - p. 3983-3987 , 2007
Link: https://doi.org/10.1016/..
 
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15

SAR of the arylpiperazine moiety of obeline somatostatin ss..:

Hurth, Konstanze ; Enz, Albert ; Floersheim, Philipp...
Bioorganic & Medicinal Chemistry Letters.  17 (2007)  14 - p. 3988-3991 , 2007
Link: https://doi.org/10.1016/..
 
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