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Lacombe, Patrick
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1

Design and synthesis of potent, isoxazole-containing renin ..:

Fournier, Pierre-André ; Arbour, Mélissa ; Cauchon, Elizabeth...
Bioorganic & Medicinal Chemistry Letters.  22 (2012)  8 - p. 2670-2674 , 2012
Link: https://doi.org/10.1016/..
 
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2

3,4-Diarylpiperidines as potent renin inhibitors:

Lacombe, Patrick ; Arbour, Mélissa ; Aspiotis, Renée...
Bioorganic & Medicinal Chemistry Letters.  22 (2012)  5 - p. 1953-1957 , 2012
Link: https://doi.org/10.1016/..
 
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3

Renin inhibitors for the treatment of hypertension: Design ..:

Chen, Austin ; Campeau, Louis-Charles ; Cauchon, Elizabeth...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  13 - p. 3970-3975 , 2011
Link: https://doi.org/10.1016/..
 
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4

Impact of passive permeability and gut efflux transport on ..:

Lévesque, Jean-François ; Bleasby, Kelly ; Chefson, Amandine...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  18 - p. 5547-5551 , 2011
Link: https://doi.org/10.1016/..
 
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5

Renin inhibitors for the treatment of hypertension: Design ..:

Chen, Austin ; Cauchon, Elizabeth ; Chefson, Amandine...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  13 - p. 3976-3981 , 2011
Link: https://doi.org/10.1016/..
 
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6

The discovery and synthesis of potent zwitterionic inhibito..:

Aspiotis, Renee ; Chen, Austin ; Cauchon, Elizabeth...
Bioorganic & Medicinal Chemistry Letters.  21 (2011)  8 - p. 2430-2436 , 2011
Link: https://doi.org/10.1016/..
 
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7

Addressing time-dependent CYP 3A4 inhibition observed in a ..:

Chen, Austin ; Dubé, Daniel ; Dubé, Laurence...
Bioorganic & Medicinal Chemistry Letters.  20 (2010)  17 - p. 5074-5079 , 2010
Link: https://doi.org/10.1016/..
 
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8

Discovery of MK-0952, a selective PDE4 inhibitor for the tr..:

Gallant, Michel ; Aspiotis, Renee ; Day, Stephen...
Bioorganic & Medicinal Chemistry Letters.  20 (2010)  22 - p. 6387-6393 , 2010
Link: https://doi.org/10.1016/..
 
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9

Identification of a new biaryl scaffold generating potent r..:

Lacombe, Patrick ; Aspiotis, Renée ; Bayly, Christopher...
Bioorganic & Medicinal Chemistry Letters.  20 (2010)  19 - p. 5822-5826 , 2010
Link: https://doi.org/10.1016/..
 
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10

Design and optimization of a substituted amino propanamide ..:

Chen, Austin ; Bayly, Christopher ; Bezençon, Olivier...
Bioorganic & Medicinal Chemistry Letters.  20 (2010)  7 - p. 2204-2209 , 2010
Link: https://doi.org/10.1016/..
 
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11

Alkyl-bridged substituted 8-arylquinolines as highly potent..:

Lacombe, Patrick ; Chauret, Nathalie ; Claveau, David...
Bioorganic & Medicinal Chemistry Letters.  19 (2009)  17 - p. 5266-5269 , 2009
Link: https://doi.org/10.1016/..
 
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12

Design, synthesis, and biological evaluation of 8-biarylqui..:

Gallant, Michel ; Chauret, Nathalie ; Claveau, David...
Bioorganic & Medicinal Chemistry Letters.  18 (2008)  4 - p. 1407-1412 , 2008
Link: https://doi.org/10.1016/..
 
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13

Nitrogen-bridged substituted 8-arylquinolines as potent PDE..:

Lacombe, Patrick ; Deschênes, Denis ; Dubé, Daniel...
Bioorganic & Medicinal Chemistry Letters.  16 (2006)  10 - p. 2608-2612 , 2006
Link: https://doi.org/10.1016/..
 
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14

Discovery of a substituted 8-arylquinoline series of PDE4 i..:

Macdonald, Dwight ; Mastracchio, Anthony ; Perrier, Hélène...
Bioorganic & Medicinal Chemistry Letters.  15 (2005)  23 - p. 5241-5246 , 2005
Link: https://doi.org/10.1016/..
 
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15

A ring closing metathesis-osmylation approach to oxygenated..:

Wong, Jerome C.Y. ; Lacombe, Patrick ; Sturino, Claudio F.
Tetrahedron Letters.  40 (1999)  50 - p. 8751-8754 , 1999
Link: https://doi.org/10.1016/..
 
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