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Mackman, Richard L.
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1

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucl..:

Mackman, Richard L. ; Kalla, Rao V. ; Babusis, Darius...
Journal of Medicinal Chemistry.  66 (2023)  17 - p. 11701-11717 , 2023
Link: https://doi.org/10.1021/..
 
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2

539. Efficacy in Multiple SARS-CoV-2 Animal Models Supports..:

Pitts, Jared ; Babusis, Darius ; Humeniuk, Rita...
Open Forum Infectious Diseases.  10 (2023)  Supplement_2 - p. , 2023
Link: https://doi.org/10.1093/..
 
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3

Phosphoramidate Prodrugs Continue to Deliver, The Journey o..:

Mackman, Richard L.
ACS Medicinal Chemistry Letters.  13 (2022)  3 - p. 338-347 , 2022
Link: https://doi.org/10.1021/..
 
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4

Intravenous delivery of GS-441524 is efficacious in the Afr..:

Pitts, Jared ; Babusis, Darius ; Vermillion, Meghan S....
Antiviral Research.  203 (2022)  - p. 105329 , 2022
Link: https://doi.org/10.1016/..
 
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5

Journey of remdesivir from the inhibition of hepatitis C vi..:

Cihlar, Tomas ; Mackman, Richard L.
Antiviral Therapy.  27 (2022)  2 - p. 135965352210827 , 2022
Link: https://doi.org/10.1177/..
 
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6

Subcutaneous remdesivir administration prevents interstitia..:

Williamson, Brandi N. ; Pérez-Pérez, Lizzette ; Schwarz, Benjamin...
Antiviral Research.  198 (2022)  - p. 105246 , 2022
Link: https://doi.org/10.1016/..
 
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7

Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside..:

Mackman, Richard L. ; Hui, Hon C. ; Perron, Michel...
Journal of Medicinal Chemistry.  64 (2021)  8 - p. 5001-5017 , 2021
Link: https://doi.org/10.1021/..
 
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8

Oral prodrug of remdesivir parent GS-441524 is efficacious ..:

Cox, Robert M. ; Wolf, Josef D. ; Lieber, Carolin M....
Nature Communications.  12 (2021)  1 - p. , 2021
Link: https://doi.org/10.1038/..
 
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9

Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Effi..:

Daffis, Stephane ; Balsitis, Scott ; Chamberlain, Jason...
Hepatology.  73 (2020)  1 - p. 53-67 , 2020
Link: https://doi.org/10.1002/..
 
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10

Discovery of GS-9688 (Selgantolimod) as a Potent and Select..:

Mackman, Richard L. ; Mish, Michael ; Chin, Gregory...
Journal of Medicinal Chemistry.  63 (2020)  18 - p. 10188-10203 , 2020
Link: https://doi.org/10.1021/..
 
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11

Structure-guided discovery of a novel, potent, and orally b..:

Sperandio, David ; Aktoudianakis, Vangelis ; Babaoglu, Kerim...
Bioorganic & Medicinal Chemistry.  27 (2019)  3 - p. 457-469 , 2019
Link: https://doi.org/10.1016/..
 
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12

Phase 1 First‐in‐Human, Single‐ and Multiple‐Ascending Dose..:

German, Polina ; Xin, Yan ; Chien, Jason W....
The Journal of Clinical Pharmacology.  58 (2018)  8 - p. 1025-1034 , 2018
Link: https://doi.org/10.1002/..
 
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13

Discovery of a Potent and Orally Bioavailable Cyclophilin I..:

Mackman, Richard L. ; Steadman, Victoria A. ; Dean, David K....
Journal of Medicinal Chemistry.  61 (2018)  21 - p. 9473-9499 , 2018
Link: https://doi.org/10.1021/..
 
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14

Lithium Chloride Catalyzed Asymmetric Domino Aza‐Michael Ad..:

Just, David ; Hernandez‐Guerra, Daniel ; Kritsch, Susanne...
European Journal of Organic Chemistry.  2018 (2018)  37 - p. 5213-5221 , 2018
Link: https://doi.org/10.1002/..
 
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15

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-..:

Agostini, Maria L. ; Andres, Erica L. ; Sims, Amy C....
mBio.  9 (2018)  2 - p. , 2018
Link: https://doi.org/10.1128/..
 
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