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Purkey, Hans E.
73  results:
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1

Quantifying KRAS G12C Covalent Drug Inhibitor Activity in M..:

Tran, John C. ; Hunsaker, Thomas ; Bell, Christina...
Analytical Chemistry.  , 2023
Link: https://doi.org/10.1021/..
 
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2

Structure-based optimization of hydroxylactam as potent, ce..:

Wei, BinQing ; Robarge, Kirk ; Labadie, Sharada S....
Bioorganic & Medicinal Chemistry Letters.  59 (2022)  - p. 128576 , 2022
Link: https://doi.org/10.1016/..
 
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3

Assessment of KRAS G12C Target Engagement by a Covalent Inh..:

Meng, Lingyao ; Chan, Emily W. ; Ng, Carl...
Analytical Chemistry.  94 (2022)  37 - p. 12927-12933 , 2022
Link: https://doi.org/10.1021/..
 
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4

Conformation-locking antibodies for the discovery and chara..:

Davies, Christopher W. ; Oh, Angela J. ; Mroue, Rana...
Nature Biotechnology.  40 (2022)  5 - p. 769-778 , 2022
Link: https://doi.org/10.1038/..
 
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5

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhi..:

Hanan, Emily J. ; Braun, Marie-Gabrielle ; Heald, Robert A....
Journal of Medicinal Chemistry.  65 (2022)  24 - p. 16589-16621 , 2022
Link: https://doi.org/10.1021/..
 
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6

Design and Evaluation of Highly Selective Human Immunoprote..:

Ladi, Ena ; Everett, Christine ; Stivala, Craig E....
Journal of Medicinal Chemistry.  62 (2019)  15 - p. 7032-7041 , 2019
Link: https://doi.org/10.1021/..
 
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7

Structural basis for dual-mode inhibition of the ABC transp..:

Ho, Hoangdung ; Miu, Anh ; Alexander, Mary Kate...
Nature.  557 (2018)  7704 - p. 196-201 , 2018
Link: https://doi.org/10.1038/..
 
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8

Discovery of a Noncovalent, Mutant-Selective Epidermal Grow..:

Chan, Bryan K. ; Hanan, Emily J. ; Bowman, Krista K....
Journal of Medicinal Chemistry.  59 (2016)  19 - p. 9080-9093 , 2016
Link: https://doi.org/10.1021/..
 
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9

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehyd..:

Purkey, Hans E. ; Robarge, Kirk ; Chen, Jinhua...
ACS Medicinal Chemistry Letters.  7 (2016)  10 - p. 896-901 , 2016
Link: https://doi.org/10.1021/..
 
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10

4-Aminoindazolyl-dihydrofuro[3,4- d ]pyrimidines as non-cov..:

Hanan, Emily J. ; Baumgardner, Matt ; Bryan, Marian C....
Bioorganic & Medicinal Chemistry Letters.  26 (2016)  2 - p. 534-539 , 2016
Link: https://doi.org/10.1016/..
 
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11

Pyridones as Highly Selective, Noncovalent Inhibitors of T7..:

Bryan, Marian C. ; Burdick, Daniel J. ; Chan, Bryan K....
ACS Medicinal Chemistry Letters.  7 (2015)  1 - p. 100-104 , 2015
Link: https://doi.org/10.1021/..
 
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12

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercapto..:

Labadie, Sharada ; Dragovich, Peter S. ; Chen, Jinhua...
Bioorganic & Medicinal Chemistry Letters.  25 (2015)  1 - p. 75-82 , 2015
Link: https://doi.org/10.1016/..
 
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13

Identification of substituted 3-hydroxy-2-mercaptocyclohex-..:

Dragovich, Peter S. ; Fauber, Benjamin P. ; Boggs, Jason...
Bioorganic & Medicinal Chemistry Letters.  24 (2014)  16 - p. 3764-3771 , 2014
Link: https://doi.org/10.1016/..
 
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14

Identification of 3,6-disubstituted dihydropyrones as inhib..:

Fauber, Benjamin P. ; Dragovich, Peter S. ; Chen, Jinhua...
Bioorganic & Medicinal Chemistry Letters.  24 (2014)  24 - p. 5683-5687 , 2014
Link: https://doi.org/10.1016/..
 
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15

Discovery of a Potent and Selective BCL-XL Inhibitor with i..:

Tao, Zhi-Fu ; Hasvold, Lisa ; Wang, Le...
ACS Medicinal Chemistry Letters.  5 (2014)  10 - p. 1088-1093 , 2014
Link: https://doi.org/10.1021/..
 
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