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Salphati, Laurent
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1

Early Stage Preclinical Formulation Strategies to Alter the..:

An, Le ; De Bruyn, Tom ; Pang, Jodie...
Pharmaceuticals.  17 (2024)  2 - p. 179 , 2024
Link: https://doi.org/10.3390/..
 
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2

Discovery and Optimization of Selective Brain-Penetrant EBP..:

Dorel, Ruth ; Sun, Dawei ; Carruthers, Nicholas...
Journal of Medicinal Chemistry.  67 (2024)  6 - p. 4819-4832 , 2024
Link: https://doi.org/10.1021/..
 
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3

Absorption, metabolism, and excretion of inavolisib (GDC-00..:

Cho, Sungjoon ; Ma, Shuguang ; Johnson, Ryan...
Drug Metabolism and Pharmacokinetics.  55 (2024)  - p. 100922 , 2024
Link: https://doi.org/10.1016/..
 
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4

Structure-based optimization of hydroxylactam as potent, ce..:

Wei, BinQing ; Robarge, Kirk ; Labadie, Sharada S....
Bioorganic & Medicinal Chemistry Letters.  59 (2022)  - p. 128576 , 2022
Link: https://doi.org/10.1016/..
 
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5

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhi..:

Hanan, Emily J. ; Braun, Marie-Gabrielle ; Heald, Robert A....
Journal of Medicinal Chemistry.  65 (2022)  24 - p. 16589-16621 , 2022
Link: https://doi.org/10.1021/..
 
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6

Growth‐rate model predicts in vivo tumor response from in v..:

Diegmiller, Rocky ; Salphati, Laurent ; Alicke, Bruno...
CPT: Pharmacometrics & Systems Pharmacology.  11 (2022)  9 - p. 1183-1193 , 2022
Link: https://doi.org/10.1002/..
 
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7

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic ..:

Chan, Bryan K. ; Seward, Eileen ; Lainchbury, Michael...
ACS Medicinal Chemistry Letters.  13 (2021)  1 - p. 84-91 , 2021
Link: https://doi.org/10.1021/..
 
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8

Structure-Based Design of Potent, Selective, and Orally Bio..:

Hu, Dennis X. ; Patel, Snahel ; Chen, Huifen...
Journal of Medicinal Chemistry.  , 2021
Link: https://doi.org/10.1021/..
 
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9

RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives ..:

Song, Kyung W. ; Edgar, Kyle A. ; Hanan, Emily J....
Cancer Discovery.  12 (2021)  1 - p. 204-219 , 2021
Link: https://doi.org/10.1158/..
 
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10

P129 - In-vivo transporter-mediated hepatic clearance of ro..:

Kumar, Vineet ; Ishida, Kazuya ; Salphati, Laurent...
Drug Metabolism and Pharmacokinetics.  35 (2020)  1 - p. S61-S62 , 2020
Link: https://doi.org/10.1016/..
 
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11

Can transporter-expressing cells predict rosuvastatin uptak..:

Kumar, Vineet ; Salphati, Laurent ; Hop, Cornelis E.C.A....
Drug Metabolism and Pharmacokinetics.  34 (2019)  1 - p. S22-S23 , 2019
Link: https://doi.org/10.1016/..
 
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12

Investigation of the absolute bioavailability and human mas..:

Ma, Shuguang ; Suchomel, Julia ; Yanez, Evelyn...
British Journal of Clinical Pharmacology.  85 (2019)  8 - p. 1751-1760 , 2019
Link: https://doi.org/10.1111/..
 
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13

Interindividual and Regional Variability in Drug Transporte..:

Billington, Sarah ; Salphati, Laurent ; Hop, Cornelis E. C. A....
Clinical Pharmacology & Therapeutics.  106 (2019)  1 - p. 228-237 , 2019
Link: https://doi.org/10.1002/..
 
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14

Does plasma membrane and total transporter abundance differ..:

Kumar, Vineet ; Salphati, Laurent ; Hop, Cornelis E.C.A....
Drug Metabolism and Pharmacokinetics.  34 (2019)  1 - p. S17 , 2019
Link: https://doi.org/10.1016/..
 
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15

Preclinical development of the PI3K Alpha selective and PIK..:

Pang, Jodie ; Baumgardner, Matthew ; Braun, Marie-Gabrielle...
Drug Metabolism and Pharmacokinetics.  34 (2019)  1 - p. S37 , 2019
Link: https://doi.org/10.1016/..
 
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