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Hybrid framework using multiple-filters and an embedded app..:

Bonilla-Huerta, Edmundo ; Hernández-Montiel, Alberto ; Morales-Caporal, Roberto.
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB).  13 (2016)  1 - p. 12-26 , 2016
Link: https://dl.acm.org/doi/10.1109/TCBB.2015.2474384