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1 Ergebnisse
1
Open Source Antibiotics: Simple Diarylimidazoles Are Potent..:
Dana M. Klug
;
Edwin G. Tse
;
Daniel G. Silva
...
doi:10.1021/acsinfecdis.3c00286.s004. , 1753
Link:
https://doi.org/10.1021/acsinfecdis.3c00286.s004
RT Journal T1
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24625883&Exemplar=1&LAN=DE A1 Dana M. Klug A1 Edwin G. Tse A1 Daniel G. Silva A1 Yafeng Cao A1 Susan A. Charman A1 Jyoti Chauhan A1 Elly Crighton A1 Maria Dichiara A1 Chris Drake A1 David Drewry A1 Flavio da Silva Emery A1 Lori Ferrins A1 Lee Graves A1 Emily Hopkins A1 Thomas A. C. Kresina A1 Álvaro Lorente-Macías A1 Benjamin Perry A1 Richard Phipps A1 Bruno Quiroga A1 Antonio Quotadamo A1 Giada N. Sabatino A1 Anthony Sama A1 Andreas Schätzlein A1 Quillon J. Simpson A1 Jonathan Steele A1 Julia Shanu-Wilson A1 Peter Sjö A1 Paul Stapleton A1 Christopher J. Swain A1 Alexandra Vaideanu A1 Huanxu Xie A1 William Zuercher A1 Matthew H. Todd YR 1753 K1 Biochemistry K1 Medicine K1 Pharmacology K1 Biotechnology K1 Cancer K1 Infectious Diseases K1 Chemical Sciences not elsewhere classified K1 staphylococcus aureus </ K1 reduced intrinsic clearance K1 private sector finds K1 open source antibiotics K1 https :// github K1 high intrinsic clearance K1 growth inhibition activity K1 diaryl imidazoles K1 diaryl imidazole K1 best overall balance K1 alternative discovery approach K1 phenotypically active compounds K1 made publicly available K1 18 compounds tested K1 widely acknowledged K1 subsequent hit K1 small array K1 simple diarylimidazoles K1 rat hepatocytes K1 progressed toward K1 potentially involved K1 opensourceantibiotics ) K1 needed medicines K1 molecular target K1 licensing terms K1 lead optimization K1 good solubility K1 good potency K1 generate much K1 eskape pathogens K1 core motifs K1 associated toxicity K1 antimicrobial resistance K1 32 μg JF doi:10.1021/acsinfecdis.3c00286.s004 LK http://dx.doi.org/https://doi.org/10.1021/acsinfecdis.3c00286.s004 DO https://doi.org/10.1021/acsinfecdis.3c00286.s004 SF ELIB - SuUB Bremen
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