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De Novo Synthesis of a Conjugative System from Human Gut Me..:
Thomas A. Hamilton
;
Benjamin R. Joris
;
Arina Shrestha
...
doi:10.1021/acssynbio.3c00319.s003. , 2023
Link:
https://doi.org/10.1021/acssynbio.3c00319.s003
RT Journal T1
De Novo Synthesis of a Conjugative System from Human Gut Metagenomic Data for Targeted Delivery of Cas9 Antimicrobials
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24735728&Exemplar=1&LAN=DE A1 Thomas A. Hamilton A1 Benjamin R. Joris A1 Arina Shrestha A1 Tyler S. Browne A1 Sébastien Rodrigue A1 Bogumil J. Karas A1 Gregory B. Gloor A1 David R. Edgell YR 2023 K1 Biochemistry K1 Medicine K1 Microbiology K1 Genetics K1 Pharmacology K1 Biotechnology K1 Cancer K1 Infectious Diseases K1 Virology K1 Space Science K1 Environmental Sciences not elsewhere classified K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 fold higher frequency K1 derived antimicrobial agents K1 >- specific sgrnas K1 54 kb containing K1 suitable candidate systems K1 metagenomic sequences requires K1 least 47 genes K1 antimicrobial delivery agent K1 adapted delivery vectors K1 uncharacterized conjugative systems K1 conjugative systems purely K1 conjugative systems present K1 large genetic systems K1 de novo </ K1 pcitro inhibited conjugation K1 citrobacter rodentium </ K1 conjugative systems K1 rodentium </ K1 citrobacter </ K1 conjugative system K1 targeted delivery K1 metagenomic data K1 genetic novelty K1 genes associated K1 conjugation components K1 based delivery K1 tray </ K1 trav </ K1 untapped source K1 typically excluded K1 tevcas9 nuclease K1 study reveals K1 starting scaffolds K1 resident plasmids K1 pcitro conjugates K1 novel target K1 human cohorts JF doi:10.1021/acssynbio.3c00319.s003 LK http://dx.doi.org/https://doi.org/10.1021/acssynbio.3c00319.s003 DO https://doi.org/10.1021/acssynbio.3c00319.s003 SF ELIB - SuUB Bremen
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