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1 Ergebnisse
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Generation and Characterization of Iduronidase-Cleavable AD..:
Sebastian Jäger
;
Doreen Könning
;
Nicolas Rasche
...
doi:10.1021/acs.bioconjchem.3c00363.s001. , 2023
Link:
https://doi.org/10.1021/acs.bioconjchem.3c00363.s001
RT Journal T1
Generation and Characterization of Iduronidase-Cleavable ADCs
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24756141&Exemplar=1&LAN=DE A1 Sebastian Jäger A1 Doreen Könning A1 Nicolas Rasche A1 Felix Hart A1 Janike Sensbach A1 Carina Krug A1 Sabine Raab-Westphal A1 Konstantin Richter A1 Carlo Unverzagt A1 Stefan Hecht A1 Jan Anderl A1 Christian Schröter YR 2023 K1 Biochemistry K1 Molecular Biology K1 Pharmacology K1 Biotechnology K1 Immunology K1 Cancer K1 Mental Health K1 Space Science K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 presented results emphasize K1 crucial design feature K1 antitumor activity could K1 analogous cathepsin b K1 several tumor types K1 established adc linkers K1 nonmalignant cells compared K1 cleavable duocarmycin adc K1 adc linker cleavage K1 nonmalignant cells K1 tumor selectivity K1 exatecan adc K1 adc pharmacokinetics K1 adc development K1 linkers must K1 iduronide linkers K1 vivo </ K1 therapeutic success K1 target cell K1 subnanomolar range K1 similar target K1 reduced toxicity K1 present study K1 normal tissues K1 mediating enzymes K1 lysosomal enzymes K1 linker system K1 interesting candidate K1 identified α K1 fundamental impact K1 efficiently release K1 cleavable adcs K1 cell lysates K1 bioinformatic screen K1 activatable valine JF doi:10.1021/acs.bioconjchem.3c00363.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.bioconjchem.3c00363.s001 DO https://doi.org/10.1021/acs.bioconjchem.3c00363.s001 SF ELIB - SuUB Bremen
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