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Discovery of YSR734: A Covalent HDAC Inhibitor with Cellula..:
Yasir S. Raouf
;
Abootaleb Sedighi
;
Mulu Geletu
...
doi:10.1021/acs.jmedchem.3c01236.s006. , 2023
Link:
https://doi.org/10.1021/acs.jmedchem.3c01236.s006
RT Journal T1
Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24767094&Exemplar=1&LAN=DE A1 Yasir S. Raouf A1 Abootaleb Sedighi A1 Mulu Geletu A1 Geordon A. Frere A1 Rebecca G. Allan A1 Nabanita Nawar A1 Elvin D. de Araujo A1 Patrick T. Gunning YR 2023 K1 Biochemistry K1 Cell Biology K1 Genetics K1 Molecular Biology K1 Pharmacology K1 Biotechnology K1 Immunology K1 Cancer K1 Chemical Sciences not elsewhere classified K1 preclinical covalent hdaci K1 powerful epigenetic modifiers K1 hdac1 – 3 K1 generation hdaci sparked K1 covalent hdac inhibitor K1 concept modified hdac2 K1 causing potent differentiation K1 catalytic domain ) K1 acute myeloid leukemia K1 >- acetyl lysines K1 specific biomarkers myogenin K1 ysr734 activated muscle K1 class covalent hdaci K1 cys274 </ sup K1 2 +</ sup K1 specific molecules K1 vivo </ K1 n </ K1 μm activity K1 ε -< K1 selective proof K1 recurring dose K1 pervasive roles K1 pentafluorobenzenesulfonamide electrophile K1 novel approaches K1 notably cancer K1 nm potency K1 limiting toxicities K1 limited cytotoxicity K1 dysregulated activity K1 current efforts K1 cellular activity K1 c2c12 myoblasts K1 broadly implicated K1 aggressive diseases K1 adme toward K1 9 fibroblasts JF doi:10.1021/acs.jmedchem.3c01236.s006 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01236.s006 DO https://doi.org/10.1021/acs.jmedchem.3c01236.s006 SF ELIB - SuUB Bremen
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