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Quabodepistat (OPC-167832), a Novel Antituberculosis Drug C..:
Nasa Sakamoto
;
Kenichi Miyata
;
Toshiro Fukami
doi:10.1021/acs.molpharmaceut.3c01059.s001. , 2023
Link:
https://doi.org/10.1021/acs.molpharmaceut.3c01059.s001
RT Journal T1
Quabodepistat (OPC-167832), a Novel Antituberculosis Drug Candidate: Enhancing Oral Bioavailability via Cocrystallization and Mechanistic Analysis of Bioavailability in Two Cocrystals
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24834223&Exemplar=1&LAN=DE A1 Nasa Sakamoto A1 Kenichi Miyata A1 Toshiro Fukami YR 2023 K1 Pharmacology K1 Biotechnology K1 Space Science K1 Environmental Sciences not elsewhere classified K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 percent dissolution differed K1 mechanistic differences underlying K1 orally administered quabodepistat K1 small intestine compared K1 improve oral bioavailability K1 dynamic ph change K1 code name opc K1 shift dissolution studies K1 2hba demonstrated supersaturation K1 two cocrystals quabodepistat K1 small intestine K1 dissolution studies K1 mechanistic analysis K1 dissolution method K1 demonstrate supersaturation K1 bioavailability studies K1 study aimed K1 poor solubility K1 performed ph K1 larger quantity K1 hydroxybenzoic acid K1 free form K1 fold greater K1 discover cocrystals K1 dihydroxybenzoic acid K1 different cocrystals K1 cocrystal form K1 beagle dogs K1 2hba remained K1 2hba dissolved K1 2hba ) JF doi:10.1021/acs.molpharmaceut.3c01059.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.molpharmaceut.3c01059.s001 DO https://doi.org/10.1021/acs.molpharmaceut.3c01059.s001 SF ELIB - SuUB Bremen
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