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1 Ergebnisse
1
A Novel Gain-of-Signal Assay to Detect Targeted Protein Deg..:
Megan Hoffman
;
Keith Ming Hong Cheah
;
K. Dane Wittrup
doi:10.1021/acssynbio.3c00447.s001. , 1753
Link:
https://doi.org/10.1021/acssynbio.3c00447.s001
RT Journal T1
A Novel Gain-of-Signal Assay to Detect Targeted Protein Degradation
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24939098&Exemplar=1&LAN=DE A1 Megan Hoffman A1 Keith Ming Hong Cheah A1 K. Dane Wittrup YR 1753 K1 Biochemistry K1 Molecular Biology K1 Pharmacology K1 Cancer K1 Science Policy K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 proposed design principles K1 previously inaccessible proteins K1 oncogenic phosphatase shp2 K1 assay platform expresses K1 target abundance rather K1 inducing targeted degradation K1 effective degraders serve K1 robust fluorescence signal K1 novel assay platform K1 expanding therapeutic development K1 signal assay K1 target protein K1 macromolecule degraders K1 detect degradation K1 signal readouts K1 signal assays K1 work demonstrates K1 utilize loss K1 promising avenue K1 novel gain K1 major bottlenecks K1 macromolecules capable K1 degrader therapies K1 current methods K1 192 candidates JF doi:10.1021/acssynbio.3c00447.s001 LK http://dx.doi.org/https://doi.org/10.1021/acssynbio.3c00447.s001 DO https://doi.org/10.1021/acssynbio.3c00447.s001 SF ELIB - SuUB Bremen
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