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1 Ergebnisse
1
Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and..:
Wenhua Jiang
;
Qiangqiang Hou
;
Hongrui Xu
...
doi:10.1021/acs.jmedchem.3c02104.s004. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c02104.s004
RT Journal T1
Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24943818&Exemplar=1&LAN=DE A1 Wenhua Jiang A1 Qiangqiang Hou A1 Hongrui Xu A1 Kexin Yang A1 Xiaohui Wang A1 Kuojun Zhang A1 Yi Zeng A1 Wenqiang Li A1 Bingrui Wang A1 Guangmei Luo A1 Xiaofan Zhao A1 Hui Shen A1 Yong Xu A1 Xiaoxing Wu YR 2024 K1 Biochemistry K1 Cell Biology K1 Pharmacology K1 Immunology K1 Cancer K1 Hematology K1 Infectious Diseases K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 potent phenoxyaryl pyridones K1 novel phenoxyaryl pyridones K1 ion channel compared K1 acute myeloid leukemia K1 remarkably improved selectivity K1 safe bet inhibitors K1 >- bet inhibitors K1 8 μm ) K1 23 </ b K1 10 </ b K1 selective bet inhibitors K1 50 </ sub K1 selective bet inhibition K1 selective lead K1 vivo </ K1 vitro </ K1 pan </ K1 high selectivity K1 30 μm K1 work provides K1 terminal domain K1 safety profiles K1 related gene K1 promising strategy K1 human ether K1 g1 arrest K1 fold ) K1 cell lines K1 antitumor efficacy K1 anticancer agents K1 9 nm K1 0 nm JF doi:10.1021/acs.jmedchem.3c02104.s004 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c02104.s004 DO https://doi.org/10.1021/acs.jmedchem.3c02104.s004 SF ELIB - SuUB Bremen
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