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1 Ergebnisse
1
New Imidazodiazepine Analogue, 5‑(8-Bromo-6-(pyridin-2-yl)‑..:
Dishary Sharmin
;
Branka Divović
;
Xingjie Ping
...
doi:10.1021/acschemneuro.3c00555.s001. , 2024
Link:
https://doi.org/10.1021/acschemneuro.3c00555.s001
RT Journal T1
New Imidazodiazepine Analogue, 5‑(8-Bromo-6-(pyridin-2-yl)‑4 H ‑benzo[ f ]imidazo[1,5‑ a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24944613&Exemplar=1&LAN=DE A1 Dishary Sharmin A1 Branka Divović A1 Xingjie Ping A1 Rok Cerne A1 Jodi L. Smith A1 Sepideh Rezvanian A1 Prithu Mondal A1 Michelle Jean Meyer A1 Molly E. Kiley A1 Leggy A. Arnold A1 Md Yeunus Mian A1 Kamal P. Pandey A1 Xiaoming Jin A1 Jelena R. Mitrović A1 Djordje Djorović A1 Arnold Lippa A1 James M. Cook A1 Lalit K. Golani A1 Petra Scholze A1 Miroslav M. Savić A1 Jeffrey M. Witkin YR 2024 K1 Biophysics K1 Biochemistry K1 Molecular Biology K1 Neuroscience K1 Pharmacology K1 Evolutionary Biology K1 Ecology K1 Mental Health K1 Chemical Sciences not elsewhere classified K1 ≥ 240 mm K1 simplified synthetic scheme K1 produces antiseizure efficacy K1 potential molecular mechanism K1 molecular docking studies K1 mesial temporal lobe K1 local field potentials K1 cortical slice preparations K1 bromophenyl )( pyridin K1 broad antiseizure efficacy K1 >‑ benzo [< K1 2yl ) methanone K1 potential backup compound K1 low sedative burden K1 functionally impact gabaars K1 gabaar binding occurred K1 81 moves forward K1 6 -( pyridin K1 5 ‑( 8 K1 new imidazodiazepine analogue K1 high oral plasma K1 yl )‑ 4 K1 low compared K1 imidazodiazepine gaba K1 containing gabaars K1 backup molecule K1 oral exposure K1 oral administration K1 ethynyl analogue K1 brominated analogue K1 tonic seizures K1 tonic convulsions K1 showed decreases K1 pharmacoresistant epilepsy K1 pharmacologically characterized K1 palladium catalyst K1 overall yield K1 neural networks K1 lethality induced K1 induce cytotoxicity K1 impairing effects JF doi:10.1021/acschemneuro.3c00555.s001 LK http://dx.doi.org/https://doi.org/10.1021/acschemneuro.3c00555.s001 DO https://doi.org/10.1021/acschemneuro.3c00555.s001 SF ELIB - SuUB Bremen
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