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1 Ergebnisse
1
Structure–Activity Relationships and Discovery of ( S )‑6-I..:
Dimitar Gotchev
;
Bruce D. Dorsey
;
Duyan Nguyen
...
doi:10.1021/acs.jmedchem.3c01981.s001. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c01981.s001
RT Journal T1
Structure–Activity Relationships and Discovery of ( S )‑6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro‑6 H ‑pyrido[1,2‑ h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24962561&Exemplar=1&LAN=DE A1 Dimitar Gotchev A1 Bruce D. Dorsey A1 Duyan Nguyen A1 Ramesh Kakarla A1 Benjamin Dugan A1 Shuai Chen A1 Min Gao A1 Laurèn Bailey A1 Fei Liu A1 Troy Harasym A1 Tim Chiu A1 Sunny Tang A1 Amy C.-H. Lee A1 Andrew G. Cole A1 Michael J. Sofia YR 2024 K1 Biochemistry K1 Medicine K1 Pharmacology K1 Immunology K1 Cancer K1 Infectious Diseases K1 Virology K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 treatment include nucleos K1 showed acceptable tolerability K1 especially surface antigen K1 dog toxicity studies K1 clinical development candidate K1 3 -( 3 K1 dihydro ‑ 6 K1 hepatitis b virus K1 methoxypropoxy )- 10 K1 452 </ b K1 >)‑ 6 K1 452 ) K1 work focuses K1 vivo </ K1 vitro </ K1 viral proteins K1 rarely lead K1 oral exposure K1 multiple species K1 interferon alpha K1 integrated genome K1 inhibiting papd5 K1 high degree K1 h </ K1 day rat K1 current treatments K1 carboxylic acid K1 >‑ pyrido JF doi:10.1021/acs.jmedchem.3c01981.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01981.s001 DO https://doi.org/10.1021/acs.jmedchem.3c01981.s001 SF ELIB - SuUB Bremen
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