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Inhaled JAK Inhibitor GDC-0214 Nanoaggregate Powder Exhibit..:
Chaeho Moon
;
Sawittree Sahakijpijarn
;
Esther Y. Maier
...
doi:10.1021/acs.molpharmaceut.3c00719.s001. , 2024
Link:
https://doi.org/10.1021/acs.molpharmaceut.3c00719.s001
RT Journal T1
Inhaled JAK Inhibitor GDC-0214 Nanoaggregate Powder Exhibits Improved Pharmacokinetic Profile in Rats Compared to the Micronized Form: Benefits of Thin Film Freezing
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_24991432&Exemplar=1&LAN=DE A1 Chaeho Moon A1 Sawittree Sahakijpijarn A1 Esther Y. Maier A1 David R. Taft A1 Miguel O. Jara A1 Tuangrat Praphawatvet A1 Rachana Manandhar A1 Nivedita Shetty A1 Joseph Lubach A1 Ajit Narang A1 Karthik Nagapudi A1 Robert O. Williams YR 2024 K1 Biochemistry K1 Medicine K1 Microbiology K1 Cell Biology K1 Pharmacology K1 Biotechnology K1 Immunology K1 Developmental Biology K1 Cancer K1 Science Policy K1 Infectious Diseases K1 Space Science K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 thin film freezing K1 fold higher ratio K1 enhanced therapeutic efficacy K1 achieve increased potency K1 improved dry powder K1 capsules containing powder K1 rat pk study K1 0214 powder administered K1 0214 nanoaggregates produced K1 dry powder inhalation K1 plasma exposures compared K1 micronized crystalline gdc K1 il )- 4 K1 0214 nanoaggregates K1 powder formulation K1 powder conditioning K1 rats compared K1 micronized form K1 tff provided K1 tff ) K1 systemic toxicity K1 successfully achieved K1 still needed K1 specifically targeting K1 selective target K1 reduced number K1 lowest auc K1 lower risk K1 janus kinase K1 jak inhibitor K1 including interleukin K1 highest auc K1 formulation f20 K1 contains 80 K1 allergic cytokines K1 air flow JF doi:10.1021/acs.molpharmaceut.3c00719.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.molpharmaceut.3c00719.s001 DO https://doi.org/10.1021/acs.molpharmaceut.3c00719.s001 SF ELIB - SuUB Bremen
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