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1 Ergebnisse
1
Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors ..:
Karishma Kailass
;
Dominick Casalena
;
Lina Jenane
...
doi:10.1021/acs.jmedchem.3c01850.s001. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c01850.s001
RT Journal T1
Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_25055144&Exemplar=1&LAN=DE A1 Karishma Kailass A1 Dominick Casalena A1 Lina Jenane A1 Gregor McEdwards A1 Douglas S. Auld A1 Oleg Sadovski A1 Esther G. Kaye A1 Elyse Hudson A1 David Nettleton A1 Mark A. Currie A1 Andrew A. Beharry YR 2024 K1 Biophysics K1 Biochemistry K1 Cell Biology K1 Molecular Biology K1 Pharmacology K1 Biotechnology K1 Immunology K1 Cancer K1 Chemical Sciences not elsewhere classified K1 pancreatic ductal adenocarcinoma K1 indicating cell permeability K1 primary enzyme responsible K1 discover 18 small K1 strong binding affinity K1 inhibitors demonstrate selectivity K1 ces2 inhibition presents K1 molecule ces2 inhibitors K1 binding small K1 show inhibition K1 purified enzyme K1 binding mechanism K1 inhibitors displayed K1 ultimately controlling K1 threatening diarrhea K1 pdac ) K1 including life K1 harmful effects K1 effective strategy K1 directly alter K1 carboxylesterase 2 K1 based treatments K1 alternate strategies K1 activatable conversion JF doi:10.1021/acs.jmedchem.3c01850.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01850.s001 DO https://doi.org/10.1021/acs.jmedchem.3c01850.s001 SF ELIB - SuUB Bremen
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