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1
Synthesis of Self Permeable Antisense PMO Using C5-Guanidin..:
Arnab Das
;
Shalini Gupta
;
Pallab Shaw
.
doi:10.1021/acs.molpharmaceut.3c00924.s001. , 1753
Link:
https://doi.org/10.1021/acs.molpharmaceut.3c00924.s001
RT Journal T1
Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5′-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_25164747&Exemplar=1&LAN=DE A1 Arnab Das A1 Shalini Gupta A1 Pallab Shaw A1 Surajit Sinha YR 1753 K1 Biophysics K1 Biochemistry K1 Pharmacology K1 Biotechnology K1 Cancer K1 Space Science K1 Environmental Sciences not elsewhere classified K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 varied cytoplasmic distribution K1 stemness marker sox2 K1 enhanced mrna binding K1 different tethering groups K1 cell permeable hiv K1 cannot form lipoplexes K1 5 ′- end K1 4 guanidinium groups K1 arginine rich stretch K1 full length pmo K1 flexible guanidinium units K1 several molecular transporters K1 pmo mediated downregulation K1 guanidinium units K1 protein downregulation K1 stretch </ K1 desired stretch K1 tat peptide K1 oligonucleotide therapeutics K1 neutral backbone K1 modified bases K1 mb 231 K1 huge challenge K1 functionalized pyrimidines K1 could solve K1 cholesterol conjugation K1 c5 position K1 assimilated within K1 antisense oligonucleotide JF doi:10.1021/acs.molpharmaceut.3c00924.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.molpharmaceut.3c00924.s001 DO https://doi.org/10.1021/acs.molpharmaceut.3c00924.s001 SF ELIB - SuUB Bremen
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