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1 Ergebnisse
1
Discovery of Potent and Selective Quinoxaline-Based Proteas..:
Xiaojun Zhang
;
Wen Jiang
;
Jeremy M. Richter
...
doi:10.1021/acs.jmedchem.3c01986.s001. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c01986.s001
RT Journal T1
Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_25265479&Exemplar=1&LAN=DE A1 Xiaojun Zhang A1 Wen Jiang A1 Jeremy M. Richter A1 J. Alex Bates A1 Samuel K. Reznik A1 Sylwia Stachura A1 Richard Rampulla A1 Dyamanna Doddalingappa A1 Sankar Ulaganathan A1 Ji Hua A1 Jeffrey S. Bostwick A1 Chi Sum A1 Shana Posy A1 Sarah Malmstrom A1 Joyce Dickey A1 David Harden A1 R. Michael Lawrence A1 Victor R. Guarino A1 William A. Schumacher A1 Pancras Wong A1 Jing Yang A1 David A. Gordon A1 Ruth R. Wexler A1 E. Scott Priestley YR 2024 K1 Biochemistry K1 Medicine K1 Cell Biology K1 Pharmacology K1 Evolutionary Biology K1 Ecology K1 Immunology K1 Inorganic Chemistry K1 Hematology K1 Infectious Diseases K1 Computational Biology K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 promising antithrombotic target K1 positional sar scanning K1 low μm potency K1 cynomolgus monkey models K1 current antiplatelet therapies K1 activated receptor 4 K1 2 nm ic K1 bleeding risk relative K1 arterial thrombosis par4 K1 50 </ sub K1 3 </ b K1 based hts hit K1 selective par4 antagonists K1 hts hit K1 minimal bleeding K1 based protease K1 par4 activation K1 selective quinoxaline K1 rich plasma K1 lead compound K1 benzothiazole series JF doi:10.1021/acs.jmedchem.3c01986.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01986.s001 DO https://doi.org/10.1021/acs.jmedchem.3c01986.s001 SF ELIB - SuUB Bremen
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