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1 Ergebnisse
1
Cyclization Scaffolding for Improved Vaccine Immunogen Stab..:
Shawn C. C. Hsueh
;
Mark Nijland
;
Adekunle Aina
.
doi:10.1021/acs.jcim.3c01556.s001. , 2024
Link:
https://doi.org/10.1021/acs.jcim.3c01556.s001
RT Journal T1
Cyclization Scaffolding for Improved Vaccine Immunogen Stability: Application to Tau Protein in Alzheimer's Disease
UL https://suche.suub.uni-bremen.de/peid=base-ftdeakinunifig:oai:figshare.com:article_25326219&Exemplar=1&LAN=DE A1 Shawn C. C. Hsueh A1 Mark Nijland A1 Adekunle Aina A1 Steven S. Plotkin YR 2024 K1 Biophysics K1 Biochemistry K1 Medicine K1 Cell Biology K1 Biotechnology K1 Cancer K1 Computational Biology K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 Information Systems not elsewhere classified K1 vaccine immunogen design K1 two cyclized constructs K1 two cyclic constructs K1 oligomeric structural mimic K1 multiple cyclic peptides K1 molecular dynamics simulations K1 lowercase letters indicate K1 free energy required K1 free energy calculations K1 cyclo -( vksekldfkdrvqskiyvg K1 cyclo -( vksekldfkdrvqskifyn K1 conjugated peptide constructs K1 protein misfolding diseases K1 previous computational work K1 conformational properties similar K1 vitro tau oligomers K1 effectively design immunogens K1 disease effective scaffolding K1 cyclization scaffolding method K1 cyclization scaffolding K1 tau protein K1 conformational space K1 computational results K1 tau fibril K1 cyclization results K1 thermodynamic stability K1 structurally resemble K1 significant stabilization K1 prone region K1 parkinson ' K1 like structures K1 involving liposome K1 identified sequences K1 holds promise K1 distal chain K1 alzheimer ' K1 active immunization JF doi:10.1021/acs.jcim.3c01556.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jcim.3c01556.s001 DO https://doi.org/10.1021/acs.jcim.3c01556.s001 SF ELIB - SuUB Bremen
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