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p16 protein is upregulated in a stepwise fashion in colorec..:

Mahmoud Al-Ahwal ; Wafaey Gomaa ; Eman Emam...
http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=6;spage=435;epage=440;aulast=Al-Ahwal.  , 2016
Link: https://doi.org/10.4103/1319-3767.195560