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1 Ergebnisse
1
Discovery, Optimization, and Evaluation of Novel Pyridin-2(..:
Zichao Xu
;
Xia Peng
;
Renjie Zhang
...
doi:10.1021/acs.jmedchem.3c01645.s006. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c01645.s006
RT Journal T1
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1 H )‑one Analogues as Potent TRK Inhibitors for Cancer Treatment
UL https://suche.suub.uni-bremen.de/peid=base-ftgriffithunifig:oai:figshare.com:article_25008534&Exemplar=1&LAN=DE A1 Zichao Xu A1 Xia Peng A1 Renjie Zhang A1 Yinchun Ji A1 Mengke You A1 Danyi Wang A1 Yanyan Shen A1 Mingyue Zheng A1 Chunpu Li A1 Jing Ai A1 Hong Liu YR 2024 K1 Biochemistry K1 Cell Biology K1 Pharmacology K1 Biotechnology K1 Cancer K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 dependent cell viability K1 based drug design K1 >)‑ one analogues K1 >)- one scaffold K1 tumor growth inhibition K1 thereby inhibiting trk K1 potent trk inhibitors K1 potent trk inhibitor K1 promising hit compound K1 good kinase selectivity K1 4 </ b K1 14q </ b K1 vivo </ K1 tumor occurrence K1 h </ K1 subcutaneous m091 K1 oral bioavailability K1 oncogenic form K1 novel pyridin JF doi:10.1021/acs.jmedchem.3c01645.s006 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01645.s006 DO https://doi.org/10.1021/acs.jmedchem.3c01645.s006 SF ELIB - SuUB Bremen
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