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1 Ergebnisse
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Identification of Chemical Scaffolds Targeting Drug-Resista..:
Summaya Perveen
;
Anjali Negi
;
Sapna Saini
..
doi:10.1021/acsinfecdis.3c00463.s001. , 1753
Link:
https://doi.org/10.1021/acsinfecdis.3c00463.s001
RT Journal T1
Identification of Chemical Scaffolds Targeting Drug-Resistant and Latent Mycobacterium tuberculosis through High-Throughput Whole-Cell Screening
UL https://suche.suub.uni-bremen.de/peid=base-ftgriffithunifig:oai:figshare.com:article_25025110&Exemplar=1&LAN=DE A1 Summaya Perveen A1 Anjali Negi A1 Sapna Saini A1 Anjali Gangwar A1 Rashmi Sharma YR 1753 K1 Biochemistry K1 Pharmacology K1 Infectious Diseases K1 Virology K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 safe therapeutic range K1 mic values ranging K1 compound chemical library K1 cell screening approach K1 although comprehensive evaluation K1 nonreplicating tuberculosis strains K1 predicted high level K1 latent mycobacterium tuberculosis K1 cell screening identification K1 seven potent compounds K1 01 exhibited synergy K1 tb drug discovery K1 mycobacterium tuberculosis K1 tuberculosis bacteria K1 tb agents K1 potent hits K1 exhibited potency K1 vivo </ K1 vitro </ K1 study employed K1 study affirms K1 promising hits K1 oral bioavailability K1 new series K1 mtb </ K1 mechanistic insights K1 low risk K1 likely due K1 intracellular model K1 initial filter K1 initial basis K1 identified hits K1 docking studies K1 displayed time K1 dependent killing K1 demonstrated efficacy K1 complementary mechanisms K1 also emphasizes K1 adverse effects K1 25 μm JF doi:10.1021/acsinfecdis.3c00463.s001 LK http://dx.doi.org/https://doi.org/10.1021/acsinfecdis.3c00463.s001 DO https://doi.org/10.1021/acsinfecdis.3c00463.s001 SF ELIB - SuUB Bremen
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