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Development of Potent Mcl‑1 Inhibitors: Structural Investig..:
Koen F. W. Hekking
;
Sergio Maroto
;
Kees van Kekem
...
doi:10.1021/acs.jmedchem.3c02206.s001. , 1753
Link:
https://doi.org/10.1021/acs.jmedchem.3c02206.s001
RT Journal T1
Development of Potent Mcl‑1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen
UL https://suche.suub.uni-bremen.de/peid=base-ftgriffithunifig:oai:figshare.com:article_25136842&Exemplar=1&LAN=DE A1 Koen F. W. Hekking A1 Sergio Maroto A1 Kees van Kekem A1 Frank S. Haasjes A1 Jack C. Slootweg A1 Patrick G. B. Oude Alink A1 Ron Dirks A1 Malvika Sardana A1 Marjon G. Bolster A1 Brian Kuijpers A1 Dennis Smith A1 Robin Doodeman A1 Marcel Scheepstra A1 Birgit Zech A1 Mark Mulvihill A1 Louis M. Renzetti A1 Lee Babiss A1 Paolo A. Centrella A1 Matthew A. Clark A1 John W. Cuozzo A1 Marie-Aude Guié A1 Eric Sigel A1 Sevan Habeshian A1 Christopher D. Hupp A1 Julie Liu A1 Heather A. Thomson A1 Ying Zhang A1 Anthony D. Keefe A1 Gerhard Müller A1 Stijn Gremmen YR 1753 K1 Biophysics K1 Biochemistry K1 Pharmacology K1 Cancer K1 Hematology K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 Information Systems not elsewhere classified K1 low nanomolar regime K1 lengthy optimization process K1 directly generate complex K1 59 </ b K1 vitro </ K1 complex molecules K1 tumor aggressiveness K1 structural investigations K1 poor survival K1 physicochemical properties K1 macrocyclic compounds K1 macrocycles originating K1 lead series K1 lead candidates K1 generally requiring K1 drug resistance K1 demonstrate fine K1 conformational analysis K1 based design K1 balanced profile K1 antiapoptotic member K1 2 family JF doi:10.1021/acs.jmedchem.3c02206.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c02206.s001 DO https://doi.org/10.1021/acs.jmedchem.3c02206.s001 SF ELIB - SuUB Bremen
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