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1 Ergebnisse
1
Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibi..:
Yongling Xu
;
Huijie Du
;
Weibo Guo
...
doi:10.1021/acs.jmedchem.3c02362.s001. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c02362.s001
RT Journal T1
Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy
UL https://suche.suub.uni-bremen.de/peid=base-ftgriffithunifig:oai:figshare.com:article_25212083&Exemplar=1&LAN=DE A1 Yongling Xu A1 Huijie Du A1 Weibo Guo A1 Beibei Liu A1 Wenxin Yan A1 Chi Zhang A1 Long Qin A1 Jingling Huang A1 Hongxia Wang A1 Shiqi Wu A1 Weijie Ren A1 Yi Zou A1 Jie Wang A1 Qihua Zhu A1 Yungen Xu A1 Hongfeng Gu YR 2024 K1 Biophysics K1 Biochemistry K1 Pharmacology K1 Biotechnology K1 Cancer K1 Space Science K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 Information Systems not elsewhere classified K1 promising therapeutic approach K1 potent inhibitory activity K1 mechanistic investigations revealed K1 cell infiltration within K1 73 nm ) K1 392 nm ) K1 syngeneic mouse model K1 orally effective small K1 highly potent small K1 cancer immunotherapy inhibition K1 x14 </ b K1 202 </ b K1 50 </ sub K1 cancer immunotherapy K1 62 nm K1 k </ K1 f </ K1 </ sub K1 mouse pd K1 l1 small K1 tumor microenvironment K1 study demonstrates K1 oral bioavailability K1 novel scaffold K1 naphthyridin scaffold K1 molecule inhibitors K1 intragastric administration K1 exhibits potential K1 effectively enhanced K1 >< sub K1 66 %) K1 10 mg K1 0 %) JF doi:10.1021/acs.jmedchem.3c02362.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c02362.s001 DO https://doi.org/10.1021/acs.jmedchem.3c02362.s001 SF ELIB - SuUB Bremen
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