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1 Ergebnisse
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Mechanistic Insights into Dibasic Iminosugars as pH-Selecti..:
Huang-Yi Li
;
Hung-Yi Lin
;
Sheng-Kai Chang
...
doi:10.1021/jacsau.3c00684.s001. , 2024
Link:
https://doi.org/10.1021/jacsau.3c00684.s001
RT Journal T1
Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human α‑Galactosidase
UL https://suche.suub.uni-bremen.de/peid=base-ftgriffithunifig:oai:figshare.com:article_25276271&Exemplar=1&LAN=DE A1 Huang-Yi Li A1 Hung-Yi Lin A1 Sheng-Kai Chang A1 Yu-Ting Chiu A1 Chung-Chien Hou A1 Tzu-Ping Ko A1 Kai-Fa Huang A1 Dau-Ming Niu A1 Wei-Chieh Cheng YR 2024 K1 Biophysics K1 Biochemistry K1 Cell Biology K1 Genetics K1 Molecular Biology K1 Physiology K1 Pharmacology K1 Inorganic Chemistry K1 Chemical Sciences not elsewhere classified K1 vicinal ammonium cations K1 two carboxyl residues K1 stabilize specific enzymes K1 stabilization using x K1 previous study found K1 findings suggest amino K1 demonstrated promising results K1 bifurcated salt bridges K1 >- substituted derivatives K1 providing new insights K1 dibasic polyhydroxylated pyrrolidine K1 physiological ph remains K1 exhibited superior ph K1 selective inhibitory activity K1 monobasic parent molecule K1 20 </ b K1 selective pharmacological chaperones K1 induced denaturation assays K1 5 </ b K1 pharmacological chaperones K1 n </ K1 selective binding K1 mechanistic insights K1 chaperoning activity K1 binding assays K1 ph 7 K1 ph 4 K1 useful models K1 therapeutic benefit K1 selective pcs K1 ray crystallography K1 protecting effects K1 mechanistic basis K1 major challenge K1 lower concentrations K1 finding attributed K1 fabry cells K1 emerging strategy K1 electrostatic repulsion K1 drug discovery K1 dibasic iminosugars JF doi:10.1021/jacsau.3c00684.s001 LK http://dx.doi.org/https://doi.org/10.1021/jacsau.3c00684.s001 DO https://doi.org/10.1021/jacsau.3c00684.s001 SF ELIB - SuUB Bremen
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