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1 Ergebnisse
1
Design, Synthesis, and Biological Evaluation of Pierardine ..:
Gaofeng Lin
;
Qinlong Xu
;
Jiaming Li
...
doi:10.1021/acs.jmedchem.3c01524.s002. , 1753
Link:
https://doi.org/10.1021/acs.jmedchem.3c01524.s002
RT Journal T1
Design, Synthesis, and Biological Evaluation of Pierardine Derivatives as Novel Brain-Penetrant and In Vivo Potent NMDAR-GluN2B Antagonists for Ischemic Stroke Treatment
UL https://suche.suub.uni-bremen.de/peid=base-ftgriffithunifig:oai:figshare.com:article_25302175&Exemplar=1&LAN=DE A1 Gaofeng Lin A1 Qinlong Xu A1 Jiaming Li A1 Zhaoxing Chu A1 Xiaodong Ma A1 Qihua Zhu A1 Yan Zhao A1 Jiajia Mo A1 Wenfeng Ye A1 Li Shao A1 Tao Fang A1 Minghan He A1 Shaoyun Yue A1 Mingqi Dai YR 1753 K1 Biochemistry K1 Molecular Biology K1 Neuroscience K1 Pharmacology K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 traditional chinese medicine K1 patch clamp assay K1 exhibited significant inhibition K1 excellent safety profiles K1 displayed favorable specificity K1 01 ± 12 K1 ischemic stroke treatment K1 glun2b binding affinity K1 </ K1 58 </ b K1 50 </ sub K1 vivo </ K1 vitro </ K1 silico </ K1 pierardine </ K1 fischer </ K1 stroke therapeutics K1 stroke candidate K1 glun2b receptor K1 glun2b antagonists K1 >< b K1 two enantiomers K1 target receptors K1 roxb .) K1 promising nmdar K1 preclinical investigation K1 potent nmdar K1 novel brain K1 mediated current K1 identified via K1 dendrobium aphyllum K1 chemical structure K1 biologically evaluated K1 biological evaluation K1 antagonistic activity K1 active ingredient K1 03 nm JF doi:10.1021/acs.jmedchem.3c01524.s002 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01524.s002 DO https://doi.org/10.1021/acs.jmedchem.3c01524.s002 SF ELIB - SuUB Bremen
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