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Metagenomic analysis of duodenal microbiota reveals a poten..:
Sroka-Oleksiak, Agnieszka
;
Młodzińska, Agata
;
Bulanda, Małgorzata
...
Journal of Clinical Medicine, T. 9, nr 2. , 2020
Link:
https://ruj.uj.edu.pl/xmlui/handle/item/257005
RT Journal T1
Metagenomic analysis of duodenal microbiota reveals a potential biomarker of dysbiosis in the course of obesity and type 2 diabetes : a pilot study
UL https://suche.suub.uni-bremen.de/peid=base-ftjagiellonuniir:oai:ruj.uj.edu.pl:item_257005&Exemplar=1&LAN=DE A1 Sroka-Oleksiak, Agnieszka A1 Młodzińska, Agata A1 Bulanda, Małgorzata A1 Salamon, Dominika A1 Major, Piotr A1 Stanek, Maciej A1 Gosiewski, Tomasz YR 2020 K1 bifidobacterium K1 duodenal microbiota K1 next-generation sequencing (NGS) K1 obesity K1 type 2 diabetes K1 Numerous scientific studies confirm that K1 apart from environmental and genetic factors K1 a significant role is played by gastrointestinal microbiota in the aetiology of type 2 diabetes and obesity. Currently K1 scientists mainly focus on the distal intestinal microbiota K1 while the equally important proximal parts of the intestine are overlooked. The aim of the study was a qualitative analysis of the structure of the duodenal mucosa microbiota in groups of patients with obesity and with type 2 diabetes and where obesity qualified for bariatric surgery: sleeve gastrectomy. The microbiological results obtained were compared with some clinical parameters. As a result K1 it was possible to determine the microbiological core that the treatment and control groups had in common K1 including phyla: Firmicutes K1 Proteobacteria K1 and Actinobacteria. The patients with obesity and with type 2 diabetes and obesity presented a significantly lower number of genus Bifidobacterium compared to healthy subjects. Furthermore K1 the numbers of Bifidobacterium were positively correlated with the high density lipoprotein (HDL) concentration in the groups under study. The obtained results indicate that bacteria of the genus Bifidobacterium should be considered in the future in the context of a potential biomarker in the progress of type 2 diabetes and obesity JF Journal of Clinical Medicine, T. 9, nr 2 LK http://dx.doi.org/https://ruj.uj.edu.pl/xmlui/handle/item/257005 DO https://ruj.uj.edu.pl/xmlui/handle/item/257005 SF ELIB - SuUB Bremen
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