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The epigenetic evolution of glioma is determined by the IDH..:

Malta, T.M ; Sabedot, T.S ; Morosini, N.S...
https://eprints.whiterose.ac.uk/207150/7/The%20epigenetic%20evolution%20of%20glioma%20is%20determined%20by%20the%20IDH1%20mutation%20status%20and%20treatment%20regimen%20.pdf.  , 2023