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Discovery of GLPG1972/S201086, a Potent, Selective, and Ora..:

Franck Brebion (2439052) ; Romain Gosmini (1738168) ; Pierre Deprez (1705699)...
https://figshare.com/articles/dataset/Discovery_of_GLPG1972_S201086_a_Potent_Selective_and_Orally_Bioavailable_ADAMTS_5_Inhibitor_for_the_Treatment_of_Osteoarthritis/14217027. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.0c02008.s002

RT Journal
T1 <Title>Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS‑5 Inhibitor for the Treatment of Osteoarthritis</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_14217027&Exemplar=1&LAN=DE
				
A1 Franck Brebion (2439052)
A1 Romain Gosmini (1738168)
A1 Pierre Deprez (1705699)
A1 Marie Varin (2479900)
A1 Christophe Peixoto (2035117)
A1 Luke Alvey (2035129)
A1 Hélène Jary (2035114)
A1 Natacha Bienvenu (1705657)
A1 Nicolas Triballeau (1400671)
A1 Roland Blanque (3989681)
A1 Céline Cottereaux (9412031)
A1 Thierry Christophe (242276)
A1 Nele Vandervoort (3989705)
A1 Patrick Mollat (206614)
A1 Robert Touitou (4376779)
A1 Philip Leonard (1621432)
A1 Frédéric De Ceuninck (1417306)
A1 Iuliana Botez (1701322)
A1 Alain Monjardet (3989687)
A1 Ellen van der Aar (3989690)
A1 David Amantini (232220)
YR 2021
K1 Biochemistry
K1 Medicine
K1 Cell Biology
K1 Neuroscience
K1 Physiology
K1 Pharmacology
K1 Biotechnology
K1 Cancer
K1 Science Policy
K1 Infectious Diseases
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 phase 2
K1 knee OA
K1 1.5 μ M
K1 DMOAD
K1 hydantoin series
K1 Biochemical activity
K1 cocrystal structure
K1 anticatabolic activity
K1 IC 50
K1 glycosaminoglycan release
K1 disease-modifying osteoarthritis
K1 mouse cartilage explants
K1 NCT
K1 GLPG
K1 aggrecanase ADAMTS
K1 HTS
K1 fluorescence-based assay
K1 AGC ELISA
JF https://figshare.com/articles/dataset/Discovery_of_GLPG1972_S201086_a_Potent_Selective_and_Orally_Bioavailable_ADAMTS_5_Inhibitor_for_the_Treatment_of_Osteoarthritis/14217027
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.0c02008.s002
DO https://doi.org/10.1021/acs.jmedchem.0c02008.s002
SF ELIB - SuUB Bremen

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